A Central Strategy for Converting Natural Products into Fluorescent Probes

Abstract

A centralized method for studying natural product chemical biology begins by designating a single fluorescent dye as a core reporter and develops through the facile conversion to a diverse panel of fluorescently labeled natural products. Comparative analyses are developed by using LED fluorescence microscopy. Application of this method is established by profiling the cellular uptake and localization of selected members of the anthracycline, acetogenin, depsipeptide, nonribosomal peptide, polyether, and polyketide families of natural products.