Discovery of BI 224436, a Noncatalytic Site Integrase Inhibitor (NCINI) of HIV-1

Lee D. Fader, Éric Malenfant, Mathieu Parisien, +32

ACS Medicinal Chemistry Letters

Hiv-1 IntegraseImmunologyMolecular BiologyPharmacotherapyBi 224436 +14

Role of the molecular weight on the mechanical properties of kappa carrageenan gels

Cyrille Rochas, Marguerite Rinaudo, Serge Landry

Carbohydrate Polymers

Biopolymer GelEngineeringMechanical PropertiesKappa Carrageenan GelsPolymer Science +4

Inhibitors of Respiratory Syncytial Virus Replication Target Cotranscriptional mRNA Guanylylation by Viral RNA-Dependent RNA Polymerase

Michel Liuzzi, Stephen W. Mason, Mireille Cartier, +17

Journal of Virology

Viral ReplicationMolecular VirologyNeurovirologyMedicineNatural Sciences +11

Relation between the molecular structure and mechanical properties of carrageenan gels

Cyrille Rochas, Marguerite Rinaudo, Serge Landry

Carbohydrate Polymers

Biopolymer GelEngineeringMechanical PropertiesCarrageenan GelsPolymer Science +4

Discovery of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of inhibitors of HIV-1 capsid assembly

Lee D. Fader, Richard C. Bethell, Pierre Bonneau, +22

Bioorganic & Medicinal Chemistry Letters

Combinatorial ChemistryMedicinal ChemistryHeterocyclicBiochemistryNatural Sciences +6

Thiotetrazole alkynylacetanilides as potent and bioavailable non-nucleoside inhibitors of the HIV-1 wild type and K103N/Y181C double mutant reverse transcriptases

Alexandre Gagnon, Ma’an Amad, Pierre Bonneau, +12

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicineNatural SciencesHuman RetrovirusAntiviral Drug Development +10

Synthesis of Propionate Motifs:  Diastereoselective Tandem Reactions Involving Anionic and Free Radical Based Processes

Yvan Guindon, Karine Houde, Michel Prévost, +5

Journal of the American Chemical Society

Cross-coupling ReactionEngineeringBiochemistryFree RadicalMukaiyama Reaction +12

Investigation on the role of the tetrazole in the binding of thiotetrazolylacetanilides with HIV-1 wild type and K103N/Y181C double mutant reverse transcriptases

Alexandre Gagnon, Serge Landry, René Coulombe, +6

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryNatural SciencesHuman RetrovirusAntiviral Drug Development +8

Scaffold hopping in the rational design of novel HIV-1 non-nucleoside reverse transcriptase inhibitors

Jeff A. O’Meara, Araz Jakalian, Steven R. LaPlante, +9

Bioorganic & Medicinal Chemistry Letters

Scaffold HoppingBiochemistryProtein FoldingRational DesignNatural Sciences +10

Intramolecular Aminyl and Iminyl Radical Additions to α,β-Unsaturated Esters. Diastereoselective Tandem Cyclofunctionalization and Hydrogen Transfer Reactions

Yvan Guindon, Brigitte Guérin, Serge Landry

Organic Letters

Asymmetric CatalysisDerivativesEngineeringSyn DiastereoselectivityOrganic Chemistry +12