Brooke D. Rakai

Metabotropic NMDA receptor signaling couples Src family kinases to pannexin-1 during excitotoxicity

Nicholas L. Weilinger, Alexander W. Lohman, Brooke D. Rakai et al. · Nature Neuroscience · 2016 · 270 citations

Life Sciences, Cell Biology, Neuroscience +12

Apabetalone (RVX-208) reduces vascular inflammation in vitro and in CVD patients by a BET-dependent epigenetic mechanism

Laura Tsujikawa, Li Fu, Shovon Das et al. · Clinical Epigenetics · 2019 · 126 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +17

BET protein inhibitor apabetalone (RVX-208) suppresses pro-inflammatory hyper-activation of monocytes from patients with cardiovascular disease and type 2 diabetes

Sylwia Wasiak, Kim E. Dzobo, Brooke D. Rakai et al. · Clinical Epigenetics · 2020 · 38 citations · Full text

Veterinary Medicine, Cardiology, Immunology +17

Survival of Adult Generated Hippocampal Neurons Is Altered in Circadian Arrhythmic Mice

Brooke D. Rakai, Michael J. Chrusch, Simon C. Spanswick et al. · PLoS ONE · 2014 · 35 citations · Full text

Life Sciences, Biology, Neuroscience +17

Epigenetic BET reader inhibitor apabetalone (RVX-208) counters proinflammatory aortic gene expression in a diet induced obesity mouse model and in human endothelial cells

Sylwia Wasiak, Laura Tsujikawa, Emily Daze et al. · Atherosclerosis · 2022 · 18 citations

Medicine, Nutritional Sciences, Pharmacology +10