Long-term evaluation of AAV-CRISPR genome editing for Duchenne muscular dystrophy

Christopher E. Nelson, Yaoying Wu, Matthew Gemberling, +9

Nature Medicine

Genome SurgeryGeneticsMolecular BiologyGenetic EngineeringGene Editing +5

The regenerative capacity of zebrafish reverses cardiac failure caused by genetic cardiomyocyte depletion

Jinhu Wang, Daniela Panáková, Kazu Kikuchi, +11

Development

Cardiac MuscleHeart FailureGeneticsCardiac RegenerationCardiovascular Function +17

Modulation of tissue repair by regeneration enhancer elements

Junsu Kang, Jianxin Hu, Ravi Karra, +7

Nature

Regenerative MedicineRegenerationEngineeringTissue TransplantationWound Healing +6

Nrg1 is an injury-induced cardiomyocyte mitogen for the endogenous heart regeneration program in zebrafish

Matthew Gemberling, Ravi Karra, Amy L. Dickson, +1

eLife

Cardiac MuscleHeart FailureCardiac Progenitor CellsCardiac RegenerationCardiovascular Function +15

Nerves Regulate Cardiomyocyte Proliferation and Heart Regeneration

Ahmed I. Mahmoud, Caitlin C. O’Meara, Matthew Gemberling, +12

Developmental Cell

MechanobiologyCardiac MuscleCardiomyopathyPhysiologyCardiac Progenitor Cells +5

<i>In vivo</i> monitoring of cardiomyocyte proliferation to identify chemical modifiers of heart regeneration

Wen-Yee Choi, Matthew Gemberling, Jinhu Wang, +4

Development

Cardiac MuscleLive Zebrafish EmbryosCardiac Progenitor CellsCardiac RegenerationCardiovascular Function +26

RNA-guided transcriptional silencing in vivo with S. aureus CRISPR-Cas9 repressors

Pratiksha I. Thakore, Jennifer B. Kwon, Christopher E. Nelson, +4

Nature Communications

A general mechanism for transcription regulation by Oct1 and Oct4 in response to genotoxic and oxidative stress

Jinsuk Kang, Matthew Gemberling, Mitsuhiro Nakamura, +4

Genes & Development

Inducible Oct1 TargetsMolecular RegulationGeneticsLipid PeroxidationEpigenetics +19

Resolving Heart Regeneration by Replacement Histone Profiling

Joseph Goldman, Guray Kuzu, Nutishia Lee, +8

Developmental Cell

Regenerative MedicineChromatinDevelopmental BiologyChromatin RemodelingEpigenomics +7

Transgenic mice for in vivo epigenome editing with CRISPR-based systems

Matthew Gemberling, Keith Siklenka, Erica Rodriguez, +20

Nature Methods

Knockout MouseOff-target EffectDevelopmental BiologyCell ModificationTransgenic Mouse Models +11