Robert Downham

Discovery of (2,4-Dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl]methanone (AT13387), a Novel Inhibitor of the Molecular Chaperone Hsp90 by Fragment Based Drug Design

Andrew Woodhead, Hayley C. Angove, Maria G. Carr et al. · Journal of Medicinal Chemistry · 2010 · 258 citations

Pharmaceutical Science, Novel Inhibitor, Drug Target +19

Fragment-Based Drug Discovery Applied to Hsp90. Discovery of Two Lead Series with High Ligand Efficiency

Christopher W. Murray, Maria G. Carr, Owen Callaghan et al. · Journal of Medicinal Chemistry · 2010 · 185 citations · Full text

Molecular Docking, High Ligand Efficiency, Medicinal Chemistry +15

Identification of Inhibitors of Protein Kinase B Using Fragment-Based Lead Discovery

Gordon Saxty, Steven J. Woodhead, Valério Berdini et al. · Journal of Medicinal Chemistry · 2007 · 138 citations · Full text

Molecular Docking, Medicinal Chemistry, Drug Target +14

Total Synthesis of (−)-Sarain A

Michael Becker, Peter Chua, Robert Downham et al. · Journal of the American Chemical Society · 2007 · 110 citations

Engineering, Biochemistry, Ring-closing Metathesis +12

Total synthesis of the protein phosphatase inhibitor okadaic acid

Steven V. Ley, Alexander C. Humphries, Holger Eick et al. · Journal of the Chemical Society Perkin Transactions 1 · 1998 · 65 citations

Medicinal Chemistry, Biosynthesis, Bioorganic Chemistry +11