Neville McLean

GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER+ Breast Cancer

Jun Liang, Robert A. Blake, Jae H. Chang et al. · Journal of Medicinal Chemistry · 2021 · 135 citations · Full text

Medicine, Oncology, Pharmacology +15

The Rational Design of Selective Benzoxazepin Inhibitors of the α-Isoform of Phosphoinositide 3-Kinase Culminating in the Identification of ( <i>S</i> )-2-((2-(1-Isopropyl-1 <i>H</i> -1,2,4-triazol-5-yl)-5,6-dihydrobenzo[ <i>f</i> ]imidazo[1,2- <i>d</i> ][1,4]oxazepin-9-yl)oxy)propanamide (GDC-0326)

Timothy P. Heffron, Robert A. Heald, Chudi Ndubaku et al. · Journal of Medicinal Chemistry · 2016 · 106 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

Stereocontrolled Synthesis of (−)-Galanthamine

Vachiraporn Satcharoen, Neville McLean, Stephen C. Kemp et al. · Organic Letters · 2007 · 102 citations

Natural Sciences, Chemistry, Medicinal Chemistry +15

Microwave assisted Petasis boronic-Mannich reactions

Neville McLean, Heather Tye, Mark Whittaker · Tetrahedron Letters · 2003 · 64 citations

Natural Sciences, Chemistry, Physical Chemistry +5

Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling

Mark Zak, Emily J. Hanan, Patrick J. Lupardus et al. · Bioorganic & Medicinal Chemistry Letters · 2019 · 55 citations · Full text

Life Sciences, Immunology, Medicinal Chemistry +9