John P. Maxwell

Ubiquitinated PCNA Drives USP1 Synthetic Lethality in Cancer

Antoine Simoneau, Justin L. Engel, Madhavi Bandi et al. · Molecular Cancer Therapeutics · 2022 · 73 citations · Full text

Life Sciences, Genetics, Oncology +15

Discovery of TNG908: A Selective, Brain Penetrant, MTA-Cooperative PRMT5 Inhibitor That Is Synthetically Lethal with <i>MTAP</i>-Deleted Cancers

Kevin M. Cottrell, Kimberly J. Briggs, Douglas A. Whittington et al. · Journal of Medicinal Chemistry · 2024 · 67 citations · Full text

Medicine, Oncology, Pharmacology +13

Inhibitors of hepatitis C virus NS3·4A protease. Part 3: P2 proline variants

Robert B. Perni, Luc J. Farmer, Kevin M. Cottrell et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 53 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13

Mild, Fast, and Stereoselective Epoxide Opening by Ketone Enolate Anions. Application to Synthesis of the Norlignan Curculigine

Gary H. Posner, John P. Maxwell, Mehmet Kahraman · The Journal of Organic Chemistry · 2003 · 31 citations

Pharmacy, Chemistry, Medicinal Chemistry +11

Discovery of TNG462: A Highly Potent and Selective MTA-Cooperative PRMT5 Inhibitor to Target Cancers with <i>MTAP</i> Deletion

Kevin M. Cottrell, Kimberly J. Briggs, Alice Tsai et al. · Journal of Medicinal Chemistry · 2025 · 26 citations · Full text

Medicine, Oncology, Pharmacology +7