Neal F. Osborne

The Chemistry of Pseudomonic Acid. 18. Heterocyclic Replacement of the α,β-Unsaturated Ester:  Synthesis, Molecular Modeling, and Antibacterial Activity

Pamela Brown, DESMOND J. BEST, N. J. P. BROOM et al. · Journal of Medicinal Chemistry · 1997 · 80 citations · Full text

Pharmacy, Medicinal Chemistry, Microbiology +17

Molecular recognition of tyrosinyl adenylate analogues by prokaryotic tyrosyl tRNA synthetases

Pamela Brown, Christine M. Richardson, Lucy Mensah et al. · Bioorganic & Medicinal Chemistry · 1999 · 55 citations

Life Sciences, Biochemistry, Molecular Biology +10

6-(Substituted methylene)penems, potent broad spectrum inhibitors of bacterial .BETA.-lactamase. III. Structure-activity relationships of the 5-membered heterocyclic derivatives.

ISABEL S. BENNETT, N. J. P. BROOM, Gordon Bruton et al. · The Journal of Antibiotics · 1991 · 44 citations · Full text

Pharmacy, Chemistry, Medicinal Chemistry +17

Studies on the mechanism of action of (5R)-(Z)-6-(1-methyl-1,2,3-triazol-4-ylmethylene)penem-3-carboxylic acid (BRL 427 15), a potent inhibitor of bacterial β-lactamase

N. J. P. BROOM, T. H. Farmer, Neal F. Osborne et al. · Journal of the Chemical Society Chemical Communications · 1992 · 26 citations

Medicine, Medicinal Chemistry, Pharmacology +7

The chemistry of 4-mercaptoazetidin-2-ones. Part 4. Synthesis of cyclopropanespiro-2-bisnorpenicillanic acids

Neal F. Osborne · Journal of the Chemical Society Perkin Transactions 1 · 1982 · 25 citations

Pharmacy, Chemistry, Medicinal Chemistry +8