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Wei Xu, Hui Yang, Ying Liu, +19

Cancer Cell

Molecular PharmacologyAldehyde DehydrogenaseBiochemistryMedicineMetabolism +2

Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys

Yuji Nagai, Naohisa Miyakawa, Hiroyuki Takuwa, +28

Nature Neuroscience

Behavioral ModulationsBehavioral NeuroscienceMedicineBehavioural PharmacologyPhysiology +11

A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases

Mohammad S. Eram, Yudao Shen, Magdalena M. Szewczyk, +16

ACS Chemical Biology

Drug TargetEpigenetic ChangeMolecular BiologyType Iii PrmtsChemical Biology +21

In silico design of novel probes for the atypical opioid receptor MRGPRX2

Katherine Lansu, Joel Karpiak, Jing Liu, +9

Nature Chemical Biology

Functional SelectivityMedicineReceptor (Biochemistry)Mechanism Of ActionNeuropharmacology +8

Pharmacologic modulation of RNA splicing enhances anti-tumor immunity

Sydney X. Lu, Emma De Neef, James D. Thomas, +32

Cell

ImmunologyRna SplicingTumor ImmunitySplicing VariantMedicine +4

The human mu opioid receptor: modulation of functional desensitization by calcium/calmodulin-dependent protein kinase and protein kinase C

Anton Mestek, JH Hurley, L.S. Bye, +6

Journal of Neuroscience

Drug ToleranceCalcium/calmodulin-dependent Protein KinaseMolecular PainPharmacotherapyExperimental Pharmacology +22

Human natural resistance-associated macrophage protein: cDNA cloning, chromosomal mapping, genomic organization, and tissue-specific expression.

Mathieu Cellier, Gregory Govoni, Silvia M. Vidal, +7

The Journal of Experimental Medicine

Microbial PathogensCdna CloningImmunologyInnate Immune SystemInnate Immunity +15

Proteolysis Targeting Chimeras (PROTACs) of Anaplastic Lymphoma Kinase (ALK)

Chengwei Zhang, Xiaoran Han, Xiaobao Yang, +4

European Journal of Medicinal Chemistry

Cancer ResearchLymphoid NeoplasiaMedicineRadiation OncologyAnaplastic Lymphoma Kinase +1

Structure, function and pharmacology of human itch GPCRs

Can Cao, Hye Jin Kang, Isha Singh, +26

Nature

Molecular PharmacologyBiochemistryG Protein-coupled ReceptorMedicineFunctional Selectivity +4

DREADD Agonist 21 Is an Effective Agonist for Muscarinic-Based DREADDs<i>in Vitro</i>and<i>in Vivo</i>

Karen Thompson, Elham Khajehali, Sophie J. Bradley, +19

ACS Pharmacology & Translational Science