Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative.

Elisabeth Buchdunger, J. Zimmermann, Helmut Mett, +4

PubMed

Abl Protein-tyrosine KinaseCellular PharmacologyPharmacotherapyAbl ProteinsPharmaceutical Chemistry +19

Pathophysiological role of endothelin revealed by the first orally active endothelin receptor antagonist

Martine Clozel, Volker Breu, Kaspar F. Burri, +8

Nature

MedicineVascular PharmacologyPhysiologyEndothelial DysfunctionVascular Biology +3

CREST—A program for the exploration of low-energy molecular chemical space

Philipp Pracht, Stefan Grimme, Christoph Bannwarth, +10

The Journal of Chemical Physics

Renin inhibition by substituted piperidines: A novel paradigm for the inhibition of monomeric aspartic proteinases?

Christian Oefner, Alfred Binggeli, Volker Breu, +16

Chemistry & Biology

Inhibitory ActivityMedicinal ChemistryBioorganic ChemistryBiochemistryNatural Sciences +10

Orally Active Fibrinogen Receptor Antagonists. 2. Amidoximes as Prodrugs of Amidines

Thomas Weller, Leo Alig, Maureen H. Beresini, +13

Journal of Medicinal Chemistry

<i>ω</i>B97X-3c: A composite range-separated hybrid DFT method with a molecule-optimized polarized valence double-<i>ζ</i> basis set

Marcel Müller, Andreas Hansen, Stefan Grimme

The Journal of Chemical Physics

EngineeringPhysicsRange-separated Hybrid DftNatural SciencesApplied Physics +10

Substituted piperidines - highly potent renin inhibitors due to induced fit adaptation of the active site

Eric Vieira, Alfred Binggeli, Volker Breu, +11

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryFunctional SelectivityNatural SciencesMedicine +11

Methylhydrazine derivatives, a new class of cytotoxic agents

P. Zeller, Heike Gutmann, B. Hegedüs, +3

Cellular and Molecular Life Sciences

MedicineDrug DiscoveryPharmacological AgentDrug DevelopmentPharmacology +1

Phenylamino‐Pyrimidine (PAP) Derivatives: A New Class of Potent and Selective Inhibitors of Protein Kinase C (PKC)

J. Zimmermann, Giorgio Caravatti, Helmut Mett, +4

Archiv der Pharmazie

Selective InhibitorsPharmacotherapyPhenylamino-pyrimidines RepresentChemical BiologyPharmaceutical Chemistry +16

Piperidine-renin inhibitors compounds with improved physicochemical properties

Rolf Güller, Alfred Binggeli, Volker Breu, +13

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryPharmaceutical ScienceMedicineRational Drug DesignPiperidine-renin Inhibitors +4