Martin de Haan

Therapeutic hFIX Activity Achieved after Single AAV5-hFIX Treatment in Hemophilia B Patients and NHPs with Pre-existing Anti-AAV5 NABs

Anna Majowicz, Bart Nijmeijer, Margit H. Lampen et al. · Molecular Therapy — Methods & Clinical Development · 2019 · 125 citations · Full text

Medicine, Hematology, Molecular Medicine +13

AAV5-miHTT Gene Therapy Demonstrates Sustained Huntingtin Lowering and Functional Improvement in Huntington Disease Mouse Models

Elisabeth A. Spronck, Cynthia Brouwers, Astrid Vallès et al. · Molecular Therapy — Methods & Clinical Development · 2019 · 88 citations · Full text

Life Sciences, Neurology, Neuroscience +17

SLV330, a cannabinoid CB1 receptor antagonist, ameliorates deficits in the T-maze, object recognition and Social Recognition Tasks in rodents

Natasja de Bruin, Jos Prickaerts, Jos H.M. Lange et al. · Neurobiology of Learning and Memory · 2010 · 54 citations

Medicine, Neuroscience, Pharmacology +11

Optimization of viral protein ratios for production of rAAV serotype 5 in the baculovirus system

Bas Bosma, Francois du Plessis, Erich Ehlert et al. · Gene Therapy · 2018 · 54 citations · Full text

Life Sciences, Biotechnology, Molecular Biology +15

Intrastriatal Administration of AAV5-miHTT in Non-Human Primates and Rats Is Well Tolerated and Results in miHTT Transgene Expression in Key Areas of Huntington Disease Pathology

Elisabeth A. Spronck, Astrid Vallès, Margit H. Lampen et al. · Brain Sciences · 2021 · 47 citations · Full text

Medicine, Neurology, Neuroscience +17