David Ryan

Rational design of potent sialidase-based inhibitors of influenza virus replication

Mark von Itzstein, Wen‐Yang Wu, Gaik B. Kok et al. · Nature · 1993 · 1.9K citations

Pharmacy, Medicinal Chemistry, Molecular Biology +16

4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid is a highly effective inhibitor both of the sialidase (neuraminidase) and of growth of a wide range of influenza A and B viruses in vitro

Jacqueline M. Woods, Richard C. Bethell, Jonathon Alexis Coates et al. · Antimicrobial Agents and Chemotherapy · 1993 · 312 citations

Life Sciences, Microbiology, Pharmacology +12

Inhibition of influenza virus replication in mice by GG167 (4-guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid) is consistent with extracellular activity of viral neuraminidase (sialidase)

David Ryan, John R. Ticehurst, M H Dempsey et al. · Antimicrobial Agents and Chemotherapy · 1994 · 143 citations · Full text

Medicine, Infectious Diseases, Pharmacology +17

Intranasal vaccination with ISCOMATRIX® adjuvanted influenza vaccine

A.R. Coulter, Rodney Harris, Roslyn Davis et al. · Vaccine · 2003 · 102 citations

Veterinary Medicine, Immunology, Infectious Diseases +14

Effect of shear stress on expression of a recombinant protein by Chinese hamster ovary cells

Julian T. Keane, David Ryan, Peter P. Gray · Biotechnology and Bioengineering · 2002 · 101 citations

Life Sciences, Biochemistry, Cell Biology +14