Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys

Travis K. Warren, Robert Jordan, Michael K. Lo, +59

Nature

Small Molecule Gs-5734Rhesus MonkeysMedicineViral PathogenesisImmunology +8

Tsg101 and the Vacuolar Protein Sorting Pathway Are Essential for HIV-1 Budding

Jennifer Garrus, Uta K. von Schwedler, Owen Pornillos, +9

Cell

Viral ReplicationHuman RetrovirusImmunologyAntiviral ResponseVirology +7

Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-<i>f</i>][triazin-4-amino] Adenine <i>C</i>-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses

Dustin S. Siegel, Hon C. Hui, Edward Doerffler, +30

Journal of Medicinal Chemistry

Functional Surfaces of the Human Immunodeficiency Virus Type 1 Capsid Protein

Uta K. von Schwedler, Kirsten M. Stray, Jennifer Garrus, +1

Journal of Virology

Virus StructureViral ReplicationCapsid ProteinProtein FoldingMedicine +12

Assembly Properties of the Human Immunodeficiency Virus Type 1 CA Protein

Barbie K. Ganser‐Pornillos, Uta K. von Schwedler, Kirsten M. Stray, +2

Journal of Virology

Histone Deacetylase Inhibitor Romidepsin Induces HIV Expression in CD4 T Cells from Patients on Suppressive Antiretroviral Therapy at Concentrations Achieved by Clinical Dosing

Datsen G. Wei, Vicki Chiang, Elizabeth Fyne, +19

PLoS Pathogens

ImmunodeficienciesImmunologyAntiviral DrugImmunotherapyPersistent Latent Reservoir +20

Antiviral Activity of Bictegravir (GS-9883), a Novel Potent HIV-1 Integrase Strand Transfer Inhibitor with an Improved Resistance Profile

Manuel Tsiang, G.S. Jones, Joshua Goldsmith, +15

Antimicrobial Agents and Chemotherapy

HIV Gag mimics the Tsg101-recruiting activity of the human Hrs protein

Owen Pornillos, Daniel S. Higginson, Kirsten M. Stray, +7

The Journal of Cell Biology

Cobicistat (GS-9350): A Potent and Selective Inhibitor of Human CYP3A as a Novel Pharmacoenhancer

Lianhong Xu, Hongtao Liu, Bernard P. Murray, +9

ACS Medicinal Chemistry Letters

Human Cyp3aPharmacotherapyAntiviral DrugChemical BiologyPharmaceutical Chemistry +17

The Human Endosomal Sorting Complex Required for Transport (ESCRT-I) and Its Role in HIV-1 Budding

Melissa D. Stuchell, Jennifer Garrus, Bárbara Müller, +6

Journal of Biological Chemistry

Viral ReplicationImmunologyMolecular BiologyViral Structural ProteinHiv-1 Viruses +14