ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

Jaeseok Han, Sung Hoon Back, Junguk Hur, +10

Nature Cell Biology

Transcriptional RegulationCell RegulationApoptosisGene ExpressionCell Death +6

Translation Attenuation through eIF2α Phosphorylation Prevents Oxidative Stress and Maintains the Differentiated State in β Cells

Sung Hoon Back, Donalyn Scheuner, Jaeseok Han, +6

Cell Metabolism

Redox SignalingSignal TransductionBiochemistryRedox RegulatorNatural Sciences +11

IRE1α-XBP1s Induces PDI Expression to Increase MTP Activity for Hepatic VLDL Assembly and Lipid Homeostasis

Shiyu Wang, Zhouji Chen, Vivian Lam, +5

Cell Metabolism

Signal TransductionSignaling PathwayBiochemistryMolecular RegulationNatural Sciences +11

The IRE1α/XBP1s Pathway Is Essential for the Glucose Response and Protection of β Cells

Justin Hassler, Donalyn Scheuner, Shiyu Wang, +16

PLoS Biology

Molecular RegulationCellular PhysiologyInsulin SignalingOxidative StressTranscriptional Regulation +19

HLA-DR4-IE chimeric class II transgenic, murine class II-deficient mice are susceptible to experimental allergic encephalomyelitis.

Ken Ito, Hongjin Bian, M. Rosana S. Molina, +11

The Journal of Experimental Medicine

HistocompatibilityGeneticsHla ImmunogeneticsImmunodeficienciesImmunology +15

Glucagon-Like Peptide-1 Gene Therapy in Obese Diabetic Mice Results in Long-Term Cure of Diabetes by Improving Insulin Sensitivity and Reducing Hepatic Gluconeogenesis

Young-Sun Lee, Seungjin Shin, Toshikatsu Shigihara, +5

Diabetes

Translational and posttranslational regulation of XIAP by eIF2α and ATF4 promotes ER stress–induced cell death during the unfolded protein response

Nobuhiko Hiramatsu, Carissa Messah, Jaeseok Han, +3

Molecular Biology of the Cell

Molecular RegulationApoptosisImmunologyCell DeathEr Stress +16

A Self-defeating Anabolic Program Leads to β-Cell Apoptosis in Endoplasmic Reticulum Stress-induced Diabetes via Regulation of Amino Acid Flux

Dawid Krokowski, Jaeseok Han, Mridusmita Saikia, +16

Journal of Biological Chemistry

Self-defeating Anabolic ProgramApoptosisCell DeathEr StressInsulin Signaling +19

ER stress signalling through eIF2α and CHOP, but not IRE1α, attenuates adipogenesis in mice

Jaeseok Han, Rachana Murthy, Brent M. Wood, +5

Diabetologia

Redox SignalingEnergy HomeostasisTranscriptional RegulationSignal TransductionPhysiology +6

Mitophagy deficiency increases NLRP3 to induce brown fat dysfunction in mice

Myoung Seok Ko, Ji Young Yun, In‐Jeoung Baek, +18

Autophagy