Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs

Jie Jiang, Qiang Zhu, Tania F. Gendron, +38

Neuron

Natural SciencesAls/ftd-linked Repeat ExpansionsMolecular BiologyLong Non-coding RnaC9orf72 Is +3

Progranulin is Neurotrophic In Vivo and Protects against a Mutant TDP-43 Induced Axonopathy

Angela S. Laird, Annelies Van Hoecke, Louis De Muynck, +4

PLoS ONE

NeuroregenerationMolecular NeuroscienceDevelopmental BiologyAmyotrophic Lateral SclerosisMedicine +12

Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo

Sander Beel, Matthieu Moisse, Louis De Muynck, +4

Human Molecular Genetics

Restoration of Progranulin Expression Rescues Cortical Neuron Generation in an Induced Pluripotent Stem Cell Model of Frontotemporal Dementia

Susanna Raitano, Laura Ordovás, Louis De Muynck, +13

Stem Cell Reports

Microglial Upregulation of Progranulin as a Marker of Motor Neuron Degeneration

Thomas Philips, Louis De Muynck, Hoai Nguyen Thi Thu, +14

Journal of Neuropathology & Experimental Neurology

RNA Sequencing Analysis of Intracranial Aneurysm Walls Reveals Involvement of Lysosomes and Immunoglobulins in Rupture

Rachel Kleinloog, Bon H. Verweij, Pieter van der Vlies, +16

Stroke

Differentially expressed genes in Alzheimer’s disease highlighting the roles of microglia genes including OLR1 and astrocyte gene CDK2AP1

Qingqin S. Li, Louis De Muynck

Brain Behavior & Immunity - Health

The neurotrophic properties of progranulin depend on the granulin E domain but do not require sortilin binding

Louis De Muynck, Sarah Herdewyn, Sander Beel, +4

Neurobiology of Aging

NeurophysiologySortilin BindingMedicineSecretory GranulesCytoskeleton +8

Genetically Engineered iPSC-Derived FTDP-17 MAPT Neurons Display Mutation-Specific Neurodegenerative and Neurodevelopmental Phenotypes

An Verheyen, Annick Diels, Joke Reumers, +16

Stem Cell Reports

Immunologic profiles of multiple sclerosis treatments reveal shared early B cell alterations

James Dooley, Ine Pauwels, Dean Franckaert, +11

Neurology Neuroimmunology & Neuroinflammation