Bertrand Leblond

Specificity and Mechanism of Action of EHT 1864, a Novel Small Molecule Inhibitor of Rac Family Small GTPases

Adam Shutes, Cercina Onesto, Virginie Picard et al. · Journal of Biological Chemistry · 2007 · 340 citations · Full text

Life Sciences, Medicinal Chemistry, Molecular Biology +13

RAC1 Inhibition Targets Amyloid Precursor Protein Processing by γ-Secretase and Decreases Aβ Production in Vitro and in Vivo

Laurent Désiré, Jérôme Bourdin, Nadia Loiseau et al. · Journal of Biological Chemistry · 2005 · 136 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

A novel DYRK1A (Dual specificity tyrosine phosphorylation‐regulated kinase 1A) inhibitor for the treatment of Alzheimer's disease: effect on Tau and amyloid pathologies <i>in vitro</i>

Séverine Coutadeur, Hélène Benyamine, Laurence Delalonde et al. · Journal of Neurochemistry · 2014 · 111 citations

Life Sciences, Molecular Biology, Neuroscience +17

2-Substituted Estradiol Bis-sulfamates, Multitargeted Antitumor Agents:  Synthesis, In Vitro SAR, Protein Crystallography, and In Vivo Activity

Mathew P. Leese, Bertrand Leblond, Andrew Smith et al. · Journal of Medicinal Chemistry · 2006 · 108 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

Phosphorylation of CLEC-2 is dependent on lipid rafts, actin polymerization, secondary mediators, and Rac

Alice Y. Pollitt, Beata Grygielska, Bertrand Leblond et al. · Blood · 2010 · 86 citations · Full text

Life Sciences, Biochemistry, Cell Biology +16