John Braganza

Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2 <i>H</i> )-ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors

Pei‐Pei Kung, Eugene Rui, Simon Bergqvist et al. · Journal of Medicinal Chemistry · 2016 · 68 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Optimization of Potent, Selective, and Orally Bioavailable Pyrrolodinopyrimidine-Containing Inhibitors of Heat Shock Protein 90. Identification of Development Candidate 2-Amino-4-{4-chloro-2-[2-(4-fluoro-1<i>H</i>-pyrazol-1-yl)ethoxy]-6-methylphenyl}-<i>N</i>-(2,2-difluoropropyl)-5,7-dihydro-6<i>H</i>-pyrrolo[3,4-<i>d</i>]pyrimidine-6-carboxamide

Luke R. Zehnder, Michael J. Bennett, Jerry Meng et al. · Journal of Medicinal Chemistry · 2011 · 42 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain

Sharan K. Bagal, Mark D. Andrews, Bruce M. Bechle et al. · Journal of Medicinal Chemistry · 2018 · 39 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Cu-Catalyzed Hydroboration of Benzylidenecyclopropanes: Reaction Optimization, (Hetero)Aryl Scope, and Origins of Pathway Selectivity

Jose M. Medina, Taeho Kang, Tuğçe G. Erbay et al. · ACS Catalysis · 2019 · 35 citations · Full text

Natural Sciences, Chemistry, Medicinal Chemistry +14

Structure–activity relationships of triazolopyridine oxazole p38 inhibitors: Identification of candidates for clinical development

Kim F. McClure, Michael A. Letavic, Amit S. Kalgutkar et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 28 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +8