Concepedia

Marina Keul

MK

13

Publications

706

Citations

12

H-Index

2015

Active since

Affiliations

TU Dortmund University(Current)

Lead Discovery Center (Germany)

Deutschen Konsortium für Translationale Krebsforschung

University of Cologne

University Hospital Cologne

Marina Keul is an author at TU Dortmund University specializing in medicine, pharmacology, and drug discovery.

Top concepts

MedicinePharmacologyDrug DiscoveryMedicinal ChemistryDrug DevelopmentNatural SciencesChemical BiologyMolecular BiologyLung CancerBiochemistry

Publications per year

2015–2022

13

Publications

13

Overcoming EGFRG724S-mediated osimertinib resistance through unique binding characteristics of second-generation EGFR inhibitors

Jana Fassunke, Fabienne Müller, Marina Keul et al. · Nature Communications · 2018 · 139 citations · Full text

Targeting Drug Resistance in EGFR with Covalent Inhibitors: A Structure-Based Design Approach

Julian Engel, André Richters, Matthäus Getlik et al. · Journal of Medicinal Chemistry · 2015 · 112 citations · Full text

Covalent Inhibitors, Drug Target, Molecular Biology +22

Trisubstituted Pyridinylimidazoles as Potent Inhibitors of the Clinically Resistant L858R/T790M/C797S EGFR Mutant: Targeting of Both Hydrophobic Regions and the Phosphate Binding Site

Marcel Günther, Jonas Lategahn, Michael Juchum et al. · Journal of Medicinal Chemistry · 2017 · 102 citations · Full text

Drug Target, Both Hydrophobic Regions, Chemical Biology +21

Drugging the catalytically inactive state of RET kinase in RET-rearranged tumors

Dennis Plenker, M Riedel, Johannes Brägelmann et al. · Science Translational Medicine · 2017 · 63 citations · Full text

Insight into the Inhibition of Drug‐Resistant Mutants of the Receptor Tyrosine Kinase EGFR

Julian Engel, Christian Becker, Jonas Lategahn et al. · Angewandte Chemie International Edition · 2016 · 61 citations

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