Concepedia

Julian Engel

JE

14

Publications

753

Citations

14

H-Index

2014

Active since

Affiliations

TU Dortmund University(Current)

Lead Discovery Center (Germany)

Leibniz Institute for Analytical Sciences - ISAS

University of Cologne

German Cancer Research Center

Julian Engel is an author at TU Dortmund University specializing in medicine, pharmacology, and drug discovery.

Top concepts

MedicinePharmacologyDrug DiscoveryDrug DevelopmentMedicinal ChemistryLung CancerCell BiologyTumor BiologyDrug ResistancePharmacotherapy

Publications per year

2014–2019

14

Publications

14

Targeting Drug Resistance in EGFR with Covalent Inhibitors: A Structure-Based Design Approach

Julian Engel, André Richters, Matthäus Getlik et al. · Journal of Medicinal Chemistry · 2015 · 112 citations · Full text

Covalent Inhibitors, Drug Target, Molecular Biology +22

Trisubstituted Pyridinylimidazoles as Potent Inhibitors of the Clinically Resistant L858R/T790M/C797S EGFR Mutant: Targeting of Both Hydrophobic Regions and the Phosphate Binding Site

Marcel Günther, Jonas Lategahn, Michael Juchum et al. · Journal of Medicinal Chemistry · 2017 · 102 citations · Full text

Drug Target, Both Hydrophobic Regions, Chemical Biology +21

Hope and Disappointment: Covalent Inhibitors to Overcome Drug Resistance in Non-Small Cell Lung Cancer

Julian Engel, Jonas Lategahn, Daniel Rauh · ACS Medicinal Chemistry Letters · 2015 · 86 citations · Full text

Covalent Inhibitors, Pharmacotherapy, Tumor Biology +17

Drugging the catalytically inactive state of RET kinase in RET-rearranged tumors

Dennis Plenker, M Riedel, Johannes Brägelmann et al. · Science Translational Medicine · 2017 · 63 citations · Full text

Insight into the Inhibition of Drug‐Resistant Mutants of the Receptor Tyrosine Kinase EGFR

Julian Engel, Christian Becker, Jonas Lategahn et al. · Angewandte Chemie International Edition · 2016 · 61 citations

Rows per page

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