CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2

Xuguang Tai, Michelle L. Cowan, Lionel Feigenbaum, +1

Nature Immunology

InflammationInterleukin 2Autoimmune DiseaseLymphocyte DevelopmentT-regulatory Cell +9

Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation

Dorota D. Klysz, Xuguang Tai, Philippe A. Robert, +15

Science Signaling

Adaptive Immune SystemT-regulatory CellImmunologyImmune RegulationCd4 T Cell Responses +18

Response to RAG-Mediated V(D)J Cleavage by NBS1 and γ-H2AX

Hua Tang Chen, Avinash Bhandoola, Michael J. Difilippantonio, +8

Science

Dna DamageImmunologyMolecular BiologyImmunotherapyGenetic Disorders +14

Basis of CTLA-4 function in regulatory and conventional CD4+ T cells

Xuguang Tai, François Van Laethem, Leonid A. Pobezinsky, +9

Blood

Foxp3 Transcription Factor Is Proapoptotic and Lethal to Developing Regulatory T Cells unless Counterbalanced by Cytokine Survival Signals

Xuguang Tai, Batu Erman, Amala Alag, +9

Immunity

Lymphocyte DevelopmentMedicineT-regulatory CellImmunologyCell Death +9

Deletion of CD4 and CD8 Coreceptors Permits Generation of αβT Cells that Recognize Antigens Independently of the MHC

François Van Laethem, Sophia D. Sarafova, Jung‐Hyun Park, +8

Immunity

ImmunologyImmunodominanceAntigen ProcessingAutoimmunityCd4 T Cell Responses +7

Clonal deletion and the fate of autoreactive thymocytes that survive negative selection

Leonid A. Pobezinsky, Georgi S. Angelov, Xuguang Tai, +5

Nature Immunology

Developmental BiologyAutoimmune DiseaseLymphocyte DevelopmentClonal DeletionSurvive Negative Selection +10

Non-CD28 Costimulatory Molecules Present in T Cell Rafts Induce T Cell Costimulation by Enhancing the Association of TCR with Rafts

Yumi Yashiro–Ohtani, Xuyu Zhou, Kazuhito Toyo‐oka, +6

The Journal of Immunology

IL-7 signaling must be intermittent, not continuous, during CD8+ T cell homeostasis to promote cell survival instead of cell death

Motoko Y. Kimura, Leonid A. Pobezinsky, Terry I. Guinter, +5

Nature Immunology

InflammationCytokineAutoimmune DiseaseLymphocyte DevelopmentAdaptive Immune System +10

Administration of recombinant interleukin 12 prevents outgrowth of tumor cells metastasizing spontaneously to lung and lymph nodes.

Jie Mu, Jian‐Ping Zou, Norihiko Yamamoto, +6

PubMed

Lung InflammationImmunologyImmunoeditingPathologyTumor Cells +16