Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling

Evan W. Weber, Kevin R. Parker, Elena Sotillo, +23

Science

Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation

Dorota D. Klysz, Xuguang Tai, Philippe A. Robert, +15

Science Signaling

Adaptive Immune SystemT-regulatory CellImmunologyImmune RegulationCd4 T Cell Responses +18

Glucose and Glutamine Metabolism Regulate Human Hematopoietic Stem Cell Lineage Specification

Leal Oburoglu, Saverio Tardito, Vanessa Fritz, +18

Cell stem cell

Developmental BiologyMedicineStem Cell MobilizationAdult Stem CellHematology +6

Co-opting signalling molecules enables logic-gated control of CAR T cells

Aidan M. Tousley, Maria Caterina Rotiroti, Louai Labanieh, +15

Nature

Car T CellsSignal TransductionCell ControlCellular Regulatory MechanismMolecular Communication +7

Delivery of CAR-T cells in a transient injectable stimulatory hydrogel niche improves treatment of solid tumors

Abigail K. Grosskopf, Louai Labanieh, Dorota D. Klysz, +15

Science Advances

Cell TherapyEngineeringSolid TumorsImmunologyBiomedical Engineering +20

Enhanced safety and efficacy of protease-regulated CAR-T cell receptors

Louai Labanieh, Robbie G. Majzner, Dorota D. Klysz, +19

Cell

GPC2-CAR T cells tuned for low antigen density mediate potent activity against neuroblastoma without toxicity

Sabine Heitzeneder, Kristopher R. Bosse, Zhongyu Zhu, +38

Cancer Cell

FOXO1 is a master regulator of memory programming in CAR T cells

Alexander Doan, Katherine P. Mueller, Andy Y. Chen, +31

Nature

Global analysis of shared T cell specificities in human non-small cell lung cancer enables HLA inference and antigen discovery

Shin-Heng Chiou, Diane Tseng, Alexandre Reuben, +37

Immunity

Enhanced T cell effector activity by targeting the Mediator kinase module

Katherine A. Freitas, Julia A. Belk, Elena Sotillo, +18

Science