GD2-CAR T cell therapy for H3K27M-mutated diffuse midline gliomas

Robbie G. Majzner, Sneha Ramakrishna, Kristen W. Yeom, +44

Nature

CAR T cells with dual targeting of CD19 and CD22 in adult patients with recurrent or refractory B cell malignancies: a phase 1 trial

Jay Y. Spiegel, Shabnum Patel, Lori Muffly, +46

Nature Medicine

Co-opting signalling molecules enables logic-gated control of CAR T cells

Aidan M. Tousley, Maria Caterina Rotiroti, Louai Labanieh, +15

Nature

Car T CellsSignal TransductionCell ControlCellular Regulatory MechanismMolecular Communication +7

Balance of Anti-CD123 Chimeric Antigen Receptor Binding Affinity and Density for the Targeting of Acute Myeloid Leukemia

Silvia Arcangeli, Maria Caterina Rotiroti, Marco Bardelli, +6

Molecular Therapy

Car Binding AffinityMixed-phenotype Acute LeukemiaImmunologyImmunoeditingAntigen Processing +15

Transition to a mesenchymal state in neuroblastoma confers resistance to anti-GD2 antibody via reduced expression of ST8SIA1

Nathaniel W. Mabe, Min Huang, Guillermo Nicolás Dalton, +23

Nature Cancer

Neuro-oncologyGliomaNeuroblastoma ConfersAnti-gd2 AntibodyMedicine +4

Targeting CD33 in Chemoresistant AML Patient-Derived Xenografts by CAR-CIK Cells Modified with an Improved SB Transposon System

Maria Caterina Rotiroti, Chiara Buracchi, Silvia Arcangeli, +16

Molecular Therapy

CD58 Aberrations Limit Durable Responses to CD19 CAR in Large B Cell Lymphoma Patients Treated with Axicabtagene Ciloleucel but Can be Overcome through Novel CAR Engineering

Robbie G. Majzner, Matthew J. Frank, Christopher Mount, +21

Blood

Optimization of therapeutic T cell expansion in G-Rex device and applicability to large-scale production for clinical use

Elisa Gotti, Sarah Tettamanti, Silvia Zaninelli, +8

Cytotherapy

IL-3-zetakine combined with a CD33 costimulatory receptor as a dual CAR approach for safer and selective targeting of AML

Vincenzo Maria Perriello, Maria Caterina Rotiroti, I. Pisani, +19

Blood Advances

Dual Car ApproachCell TherapyImmunologySelective TargetingImmunologic Mechanism +14

Immunotherapy-related cognitive impairment after CAR T cell therapy in mice

Anna C. Geraghty, Lehi Acosta-Alvarez, Maria Caterina Rotiroti, +25

Cell