Ferroptosis is essential for diabetic cardiomyopathy and is prevented by sulforaphane via AMPK/NRF2 pathways

Xiang Wang, Xinxin Chen, Wenqian Zhou, +9

Acta Pharmaceutica Sinica B

Diabetic Downregulation of Nrf2 Activity via ERK Contributes to Oxidative Stress–Induced Insulin Resistance in Cardiac Cells In Vitro and In Vivo

Yi Tan, Tomonaga Ichikawa, Jinqing Li, +8

Diabetes

Prevention by sulforaphane of diabetic cardiomyopathy is associated with up-regulation of Nrf2 expression and transcription activation

Yang Bai, Wenpeng Cui, Ying Xin, +8

Journal of Molecular and Cellular Cardiology

Reductive StressMetabolic SyndromeCardiomyopathySignal TransductionBiochemistry +12

Metallothionein Is Downstream of Nrf2 and Partially Mediates Sulforaphane Prevention of Diabetic Cardiomyopathy

Junlian Gu, Yanli Cheng, Hao Wu, +10

Diabetes

Sulforaphane prevents the development of cardiomyopathy in type 2 diabetic mice probably by reversing oxidative stress-induced inhibition of LKB1/AMPK pathway

Zhiguo Zhang, Shudong Wang, Shanshan Zhou, +9

Journal of Molecular and Cellular Cardiology

Metabolic SyndromeLkb1/ampk PathwayCardiomyopathyBiochemistryMedicine +10

Exacerbation of diabetes-induced testicular apoptosis by zinc deficiency is most likely associated with oxidative stress, p38 MAPK activation, and p53 activation in mice

Yuguang Zhao, Yi Tan, Junying Dai, +9

Toxicology Letters

InflammationLipid PeroxidationDiabetesApoptosisPhysiology +7

Sulforaphane prevents angiotensin II-induced cardiomyopathy by activation of Nrf2 via stimulating the Akt/GSK-3ß/Fyn pathway

Ying Xin, Yang Bai, Xin Jiang, +7

Redox Biology

Elevating CXCR7 Improves Angiogenic Function of EPCs via Akt/GSK-3β/Fyn-Mediated Nrf2 Activation in Diabetic Limb Ischemia

Xiaozhen Dai, Xiaoqing Yan, Jun Zeng, +13

Circulation Research

Acceleration of diabetic wound healing with chitosan-crosslinked collagen sponge containing recombinant human acidic fibroblast growth factor in healing-impaired STZ diabetic rats

Wei Wang, Shaoqiang Lin, Yechen Xiao, +4

Life Sciences

Regenerative MedicineTissue EngineeringBiocompatible MaterialEngineeringBiomaterials Design +11

Inactivation of GSK-3β by Metallothionein Prevents Diabetes-Related Changes in Cardiac Energy Metabolism, Inflammation, Nitrosative Damage, and Remodeling

Yuehui Wang, Wenke Feng, Wanli Xue, +4

Diabetes