Metallothionein Is Downstream of Nrf2 and Partially Mediates Sulforaphane Prevention of Diabetic Cardiomyopathy

Junlian Gu, Yanli Cheng, Hao Wu, +10

Diabetes

Sulforaphane prevents the development of cardiomyopathy in type 2 diabetic mice probably by reversing oxidative stress-induced inhibition of LKB1/AMPK pathway

Zhiguo Zhang, Shudong Wang, Shanshan Zhou, +9

Journal of Molecular and Cellular Cardiology

Metabolic SyndromeLkb1/ampk PathwayCardiomyopathyBiochemistryMedicine +10

Fenofibrate increases cardiac autophagy via FGF21/SIRT1 and prevents fibrosis and inflammation in the hearts of Type 1 diabetic mice

Jingjing Zhang, Yanli Cheng, Junlian Gu, +12

Clinical Science

Heart FailureDiabetic MiceImmunologyCardiovascular PharmacologyFgf21 Gene +23

Cardioprotective effects of fibroblast growth factor 21 against doxorubicin-induced toxicity via the SIRT1/LKB1/AMPK pathway

Shudong Wang, Yonggang Wang, Zhiguo Zhang, +2

Cell Death and Disease

ImmunologyCardiovascular PharmacologyPathologyCell DeathRenal Inflammation +19

Fibroblast growth factor 21 protects the heart from apoptosis in a diabetic mouse model via extracellular signal-regulated kinase 1/2-dependent signalling pathway

Chi Zhang, Zhifeng Huang, Junlian Gu, +10

Diabetologia

FibrosisAngiogenesisDevelopmental BiologyMedicineCell Death +8

Inhibition of p53 prevents diabetic cardiomyopathy by preventing early-stage apoptosis and cell senescence, reduced glycolysis, and impaired angiogenesis

Junlian Gu, Shudong Wang, Hua Guo, +9

Cell Death and Disease

C66 ameliorates diabetic nephropathy in mice by both upregulating NRF2 function via increase in miR-200a and inhibiting miR-21

Hao Wu, Lili Kong, Yi Tan, +8

Diabetologia

InflammationMetabolic SyndromeUpregulating Nrf2 FunctionMedicineDiabetes +10

Uncoupling the Mitogenic and Metabolic Functions of FGF1 by Tuning FGF1-FGF Receptor Dimer Stability

Zhifeng Huang, Yi Tan, Junlian Gu, +13

Cell Reports

Cardiac SIRT1 ameliorates doxorubicin-induced cardiotoxicity by targeting sestrin 2

Jie Wang, Yufeng Tang, Jingjing Zhang, +7

Redox Biology

InflammationCardiovascular ToxicityHeart FailureCardiovascular DiseaseMedicine +13

Bone Marrow Mesenchymal Stem Cell-Derived Exosomal miRNA-29c Decreases Cardiac Ischemia/Reperfusion Injury Through Inhibition of Excessive Autophagy via the PTEN/Akt/mTOR Signaling Pathway

Te Li, Junlian Gu, Yang Ou, +3

Circulation Journal