Anne Jackson

Structure-Based Design and Pharmacokinetic Optimization of Covalent Allosteric Inhibitors of the Mutant GTPase KRAS^G12C

Jason G. Kettle, Sharan K. Bagal, Sue Bickerton et al. · Journal of Medicinal Chemistry · 2020 · 80 citations · Full text

Contribution of calcium-containing crystals to cartilage degradation and synovial inflammation in osteoarthritis

Y.Z. Liu, Anne Jackson, Stephen D. Cosgrove · Osteoarthritis and Cartilage · 2009 · 62 citations · Full text

Mechanobiology, Rheumatology, Musculoskeletal Research +12

Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRAS^G12C

Jason G. Kettle, Sharan K. Bagal, Sue Bickerton et al. · Journal of Medicinal Chemistry · 2022 · 56 citations · Full text

Optimization of an Imidazo[1,2-<i>a</i>]pyridine Series to Afford Highly Selective Type I1/2 Dual Mer/Axl Kinase Inhibitors with <i>In Vivo</i> Efficacy

William McCoull, Scott Boyd, Martin R. Brown et al. · Journal of Medicinal Chemistry · 2021 · 27 citations · Full text

Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRAS^G12C with Demonstrable CNS Penetration

Jason G. Kettle, Sharan K. Bagal, Derek Barratt et al. · Journal of Medicinal Chemistry · 2023 · 27 citations · Full text