Animal versus human oral drug bioavailability: Do they correlate?

Helen Musther, Andrés Olivares‐Morales, Oliver Hatley, +1

European Journal of Pharmaceutical Sciences

Oral BioavailabilityPreclinical Drug EvaluationBioavailability CalculationsBioequivalencePharmacological Study +11

Prediction of Drug-Drug Interactions Arising from CYP3A induction Using a Physiologically Based Dynamic Model

Lisa M. Almond, Sophie Mukadam, I. Gardner, +7

Drug Metabolism and Disposition

Quantitative ADME Proteomics – CYP and UGT Enzymes in the Beagle Dog Liver and Intestine

Aki T. Heikkinen, Arno Friedlein, Mariette Matondo, +10

Pharmaceutical Research

Ugt EnzymesProteomic TechnologyProtein FunctionProtein ExpressionBiochemistry +7

Pretreatment With Rifampicin and Tyrosine Kinase Inhibitor Dasatinib Potentiates the Inhibitory Effects Toward OATP1B1- and OATP1B3-Mediated Transport

Sonia Pahwa, Khondoker Alam, Alexandra Crowe, +5

Journal of Pharmaceutical Sciences

Signal TransductionMedicineReceptor Tyrosine KinaseOatp1b3-mediated TransportPharmacotherapy +3

The Use of ROC Analysis for the Qualitative Prediction of Human Oral Bioavailability from Animal Data

Andrés Olivares‐Morales, Oliver Hatley, David B. Turner, +3

Pharmaceutical Research

Prediction of CYP‐mediated DDIs involving inhibition: Approaches to address the requirements for system qualification of the Simcyp Simulator

Peter Kilford, Kuan‐Fu Chen, Kim Crewe, +6

CPT Pharmacometrics & Systems Pharmacology

Integrate mechanistic evidence from new approach methodologies (NAMs) into a read-across assessment to characterise trends in shared mode of action

Sylvia E. Escher, Alejandro Aguayo‐Orozco, Emilio Benfenati, +31

Toxicology in Vitro

Role of pharmacokinetic modeling and simulation in precision dosing of anticancer drugs

Adam S. Darwich, Kayode Ogungbenr, Oliver Hatley, +1

Translational Cancer Research

Precision DosingModel-informed Precision DosingTherapeutic Drug MonitoringOncologyPharmacokinetic Modeling +13

Development of a physiologically based pharmacokinetic (PBPK) population model for Chinese elderly subjects

Cheng Cui, Jie En Valerie Sia, Siqi Tu, +7

British Journal of Clinical Pharmacology

Quantifying gut wall metabolism: methodology matters

Oliver Hatley, Christopher R. Jones, Aleksandra Galetin, +1

Biopharmaceutics & Drug Disposition