Melanie A Rehder Silinski

Discovery of Novel 2-Aminobenzamide Inhibitors of Heat Shock Protein 90 as Potent, Selective and Orally Active Antitumor Agents

Kenneth H. Huang, James M. Veal, R. Patrick Fadden et al. · Journal of Medicinal Chemistry · 2009 · 191 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

SNX2112, a Synthetic Heat Shock Protein 90 Inhibitor, Has Potent Antitumor Activity against HER Kinase–Dependent Cancers

Sarat Chandarlapaty, Ayana Sawai, Qing Ye et al. · Clinical Cancer Research · 2008 · 184 citations

Medicine, Medicinal Chemistry, Pharmacology +14

Brain-Permeable Small-Molecule Inhibitors of Hsp90 Prevent α-Synuclein Oligomer Formation and Rescue α-Synuclein-Induced Toxicity

Preeti Putcha, Karin M. Danzer, Lisa R. Kranich et al. · Journal of Pharmacology and Experimental Therapeutics · 2009 · 180 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

Small molecule inhibitors of Hsp90 potently affect inflammatory disease pathways and exhibit activity in models of rheumatoid arthritis

John W. Rice, James M. Veal, R. Patrick Fadden et al. · Arthritis & Rheumatism · 2008 · 135 citations

Medicine, Immunology, Pharmacology +17

Application of Chemoproteomics to Drug Discovery: Identification of a Clinical Candidate Targeting Hsp90

Patrick Fadden, Kenneth H. Huang, James M. Veal et al. · Chemistry & Biology · 2010 · 88 citations

Life Sciences, Molecular Biology, Pharmacology +5