Keizo Hirase

1-[5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine Monofumarate (TAK-438), a Novel and Potent Potassium-Competitive Acid Blocker for the Treatment of Acid-Related Diseases

Yasunobu Hori, Akio Imanishi, Jun Matsukawa et al. · Journal of Pharmacology and Experimental Therapeutics · 2010 · 199 citations

Discovery of a Novel Pyrrole Derivative 1-[5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1<i>H</i>-pyrrol-3-yl]-<i>N</i>-methylmethanamine Fumarate (TAK-438) as a Potassium-Competitive Acid Blocker (P-CAB)

Yasuyoshi Arikawa, Haruyuki Nishida, Osamu Kurasawa et al. · Journal of Medicinal Chemistry · 2012 · 155 citations

Pharmaceutical Science, Bioorganic Chemistry, Potassium-competitive Acid Blocker +17

Discovery, synthesis, and biological evaluation of novel pyrrole derivatives as highly selective potassium-competitive acid blockers

Haruyuki Nishida, Atsushi Hasuoka, Yasuyoshi Arikawa et al. · Bioorganic & Medicinal Chemistry · 2012 · 46 citations

Medicinal Chemistry, Biochemistry, Natural Sciences +9

Identification of a novel fluoropyrrole derivative as a potassium-competitive acid blocker with long duration of action

Haruyuki Nishida, Yasuyoshi Arikawa, Keizo Hirase et al. · Bioorganic & Medicinal Chemistry · 2017 · 13 citations

Medicinal Chemistry, Derivatives, Potassium-competitive Acid Blocker +8