David D. Scott

Small Molecule Targeting TDP-43’s RNA Recognition Motifs Reduces Locomotor Defects in a <i>Drosophila</i> Model of Amyotrophic Lateral Sclerosis (ALS)

Liberty François‐Moutal, Razaz Felemban, David D. Scott et al. · ACS Chemical Biology · 2019 · 69 citations

Life Sciences, Molecular Biology, Neuroscience +17

Selective targeting of NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces pain in rodents

Song Cai, Aubin Moutal, Jie Yu et al. · Science Translational Medicine · 2021 · 57 citations · Full text

Medicine, Neuroscience, Pharmacology +16

The Natural Flavonoid Naringenin Elicits Analgesia through Inhibition of NaV1.8 Voltage-Gated Sodium Channels

Yuan Zhou, Song Cai, Aubin Moutal et al. · ACS Chemical Neuroscience · 2019 · 47 citations

Medicine, Neuroscience, Pharmacology +17

Heat shock protein Grp78/BiP/HspA5 binds directly to TDP-43 and mitigates toxicity associated with disease pathology

Liberty François‐Moutal, David D. Scott, Andrew J. Ambrose et al. · Scientific Reports · 2022 · 38 citations · Full text

Life Sciences, Biochemistry, Neuroscience +15

An Allosteric Modulator of RNA Binding Targeting the N-Terminal Domain of TDP-43 Yields Neuroprotective Properties

Niloufar Mollasalehi, Liberty François‐Moutal, David D. Scott et al. · ACS Chemical Biology · 2020 · 35 citations · Full text

Life Sciences, Molecular Biology, Neuroscience +17