SARS-CoV-2 spike protein co-opts VEGF-A/neuropilin-1 receptor signaling to induce analgesia

Aubin Moutal, Laurent Martin, Lisa Boinon, +11

Pain

Hierarchical CRMP2 posttranslational modifications control NaV1.7 function

Erik T. Dustrude, Aubin Moutal, Xiaofang Yang, +3

Proceedings of the National Academy of Sciences

Biophysical ModelingSynaptic TransmissionSignal RecognitionMolecular BiologyMolecular Pain +19

Long-lasting antinociceptive effects of green light in acute and chronic pain in rats

Mohab Ibrahim, Amol Patwardhan, Kerry B. Gilbraith, +8

Pain

Dysregulation of serum prolactin links the hypothalamus with female nociceptors to promote migraine

Moe Watanabe, Caroline Machado Kopruszinski, Aubin Moutal, +9

Brain

A membrane-delimited N-myristoylated CRMP2 peptide aptamer inhibits CaV2.2 trafficking and reverses inflammatory and postoperative pain behaviors

Liberty François‐Moutal, Yue Wang, Aubin Moutal, +9

Pain

CRISPR/Cas9 editing of Nf1 gene identifies CRMP2 as a therapeutic target in neurofibromatosis type 1-related pain that is reversed by (S)-Lacosamide

Aubin Moutal, Xiaofang Yang, Wennan Li, +14

Pain

Pain MedicinePathologyNeuropathic PainMolecular PainNf1 Pain +16

The prolactin receptor long isoform regulates nociceptor sensitization and opioid-induced hyperalgesia selectively in females

Yanxia Chen, Aubin Moutal, Edita Navratilova, +15

Science Translational Medicine

Prl SignalsPain MedicineNeuropathic PainMolecular PainFemale Reproductive Function +16

(S)-lacosamide inhibition of CRMP2 phosphorylation reduces postoperative and neuropathic pain behaviors through distinct classes of sensory neurons identified by constellation pharmacology

Aubin Moutal, Lindsey A. Chew, Xiaofang Yang, +14

Pain

A light-gated potassium channel for sustained neuronal inhibition

Laura Alberio, Andrea Locarno, Andrea Saponaro, +25

Nature Methods

Hyperpolarization (Biology)NeurophysiologyMedicinePhysiologyIon Channels +5

Synaptic zinc inhibition of NMDA receptors depends on the association of GluN2A with the zinc transporter ZnT1

Rebecca Krall, Aubin Moutal, Matthew B. Phillips, +6

Science Advances