Species differences and molecular determinant of TRPA1 cold sensitivity

Jun Chen, Dawon Kang, Jing Xu, +6

Nature Communications

Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-R_S

Chaohong Sun, Danying Song, Rachel Davis‐Taber, +10

Proceedings of the National Academy of Sciences

Activation of TRPA1 Channels by the Fatty Acid Amide Hydrolase Inhibitor 3′-Carbamoylbiphenyl-3-yl cyclohexylcarbamate (URB597)

Wende Niforatos, Xufeng Zhang, Marc Lake, +7

Molecular Pharmacology

An anti-PD-1–GITR-L bispecific agonist induces GITR clustering-mediated T cell activation for cancer immunotherapy

Sarah Chan, Nicole A. Belmar, Sun K. Ho, +38

Nature Cancer

Discovery, Structure−Activity Relationship, and Pharmacological Evaluation of (5-Substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as Potent Dipeptidyl Peptidase IV Inhibitors

Zhonghua Pei, Xiaofeng Li, Kenton L. Longenecker, +23

Journal of Medicinal Chemistry

Medicinal ChemistryPharmaceutical ScienceBiochemistryAffect PotencyStructure−activity Relationship +12

A Bispecific Molecule Targeting CD40 and Tumor Antigen Mesothelin Enhances Tumor-Specific Immunity

Shiming Ye, Diane Cohen, Nicole A. Belmar, +16

Cancer Immunology Research

Variants in Apaf-1 segregating with major depression promote apoptosome function

John E. Harlan, Y Chen, Earl J. Gubbins, +26

Molecular Psychiatry

Signal TransductionSignaling PathwayGeneticsApoptosisMajor Depression +6

Ligand association rates to the inner-variable-domain of a dual-variable-domain immunoglobulin are significantly impacted by linker design

Enrico L. DiGiammarino, John E. Harlan, Karl A. Walter, +8

mAbs

Utility of Large-Scale Transiently Transfected Cells for Cell-Based High-Throughput Screens to Identify Transient Receptor Potential Channel A1 (TRPA1) Antagonists

Jun Chen, Marc Lake, Reza S. Sabet, +13

SLAS DISCOVERY

Fragment-Based Discovery of an Apolipoprotein E4 (apoE4) Stabilizer

Andrew M. Petros, Alla Korepanova, Clarissa G. Jakob, +18

Journal of Medicinal Chemistry