A-317491, a novel potent and selective non-nucleotide antagonist of P2X ₃ and P2X _2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat

Michael F. Jarvis, Edward C. Burgard, Steve McGaraughty, +22

Proceedings of the National Academy of Sciences

Pharmacological characterization of recombinant human and rat P2X receptor subtypes

Bruce R. Bianchi, Kevin J. Lynch, Edward Touma, +9

European Journal of Pharmacology

Molecular PharmacologyPharmacological CharacterizationMedicinePhysiologyReceptor (Biochemistry) +4

TRPV1 Receptors in the CNS Play a Key Role in Broad-Spectrum Analgesia of TRPV1 Antagonists

Minghua Cui, Prisca Honoré, Chengmin Zhong, +17

Journal of Neuroscience

Pain MedicineTrpv1 AntagonistsImmunologyNeuropathic PainMolecular Pain +15

Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation

Jun Chen, Shailen K. Joshi, Stanley DiDomenico, +19

Pain

Structure−Activity Relationship Studies on a Series of Novel, Substituted 1-Benzyl-5-phenyltetrazole P2X₇Antagonists

Derek W. Nelson, Robert J. Gregg, Michael E. Kort, +11

Journal of Medicinal Chemistry

Molecular PainOrganic ChemistryPharmacotherapyChemistryPharmaceutical Chemistry +18

Involvement of the TTX-resistant sodium channel Nav 1.8 in inflammatory and neuropathic, but not post-operative, pain states

S. K. Joshi, Joseph P. Mikusa, Gricelda Hernandez, +12

Pain

P2X Receptor–Mediated Ionic Currents in Dorsal Root Ganglion Neurons

Edward C. Burgard, Wende Niforatos, Tim van Biesen, +5

Journal of Neurophysiology

Synaptic TransmissionNeuropathic PainMolecular PainAtp Analogue AlphaNeurotransmission +21

A-425619 [1-Isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a Novel and Selective Transient Receptor Potential Type V1 Receptor Antagonist, Blocks Channel Activation by Vanilloids, Heat, and Acid

Rachid El Kouhen, Carol S. Surowy, Bruce R. Bianchi, +9

Journal of Pharmacology and Experimental Therapeutics

Molecular and Functional Characterization of Human P2X₂Receptors

Kevin J. Lynch, Edward Touma, Wende Niforatos, +5

Molecular Pharmacology

Alteration of dorsal root ganglion P2X 3 receptor expression and function following spinal nerve ligation in the rat

Karen Kage, Wende Niforatos, Chang Zhu, +3

Experimental Brain Research

Spinal Cord InjuryPeripheral Nerve InjuryPhysiologyMolecular PainSpinal Nerve Ligation +7