Marianne Schimpl

GlcNAcstatin:  a Picomolar, Selective <i>O</i>-GlcNAcase Inhibitor That Modulates Intracellular <i>O</i>-GlcNAcylation Levels

Helge C. Dorfmueller, Vladimir S. Borodkin, Marianne Schimpl et al. · Journal of the American Chemical Society · 2006 · 143 citations · Full text

O-GlcNAc transferase invokes nucleotide sugar pyrophosphate participation in catalysis

Marianne Schimpl, Xiaowei Zheng, Vladimir S. Borodkin et al. · Nature Chemical Biology · 2012 · 134 citations · Full text

Biosynthesis, Bioorganic Chemistry, Cellular Enzymology +8

The active site of O-GlcNAc transferase imposes constraints on substrate sequence

Shalini Pathak, Jana Alonso, Marianne Schimpl et al. · Nature Structural & Molecular Biology · 2015 · 129 citations

Cellular Enzymology, Biochemistry, Natural Sciences +9

Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}-<i>N</i>-methylpyridine-2-carboxamide (AZD5305): A PARP1–DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs

Jeffrey W. Johannes, Amber Balazs, Derek Barratt et al. · Journal of Medicinal Chemistry · 2021 · 129 citations · Full text

GlcNAcstatins are nanomolar inhibitors of human <i>O</i>-GlcNAcase inducing cellular hyper-<i>O</i>-GlcNAcylation

Helge C. Dorfmueller, Vladimir S. Borodkin, Marianne Schimpl et al. · Biochemical Journal · 2009 · 89 citations · Full text

Nanomolar Inhibitors, Glycobiology, Molecular Biology +19