Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemia

Daniel A. Pollyea, Brett M. Stevens, Courtney L. Jones, +14

Nature Medicine

Hematological MalignancyMedicineAcute Myeloid LeukemiaStem CellsPharmacology +7

Monocytic Subclones Confer Resistance to Venetoclax-Based Therapy in Patients with Acute Myeloid Leukemia

Shanshan Pei, Daniel A. Pollyea, Annika Gustafson, +29

Cancer Discovery

Mixed-phenotype Acute LeukemiaImmunologyPharmacotherapyImmunotherapyDrug Resistance +17

The Na+-dependent chloride-bicarbonate exchanger SLC4A8 mediates an electroneutral Na+ reabsorption process in the renal cortical collecting ducts of mice

F. Leviel, Christian A. Hübner, Pascal Houillier, +17

Journal of Clinical Investigation

Renal FunctionSodium BalanceSodium HomeostasisMedicineIsolated Ccds +10

Single-cell RNA sequencing identifies TGF-β as a key regenerative cue following LPS-induced lung injury

Kent Riemondy, Nicole L. Jansing, Peng Jiang, +8

JCI Insight

Neoplastic and immune single-cell transcriptomics define subgroup-specific intra-tumoral heterogeneity of childhood medulloblastoma

Kent Riemondy, Sujatha Venkataraman, Nicholas Willard, +18

Neuro-Oncology

Childhood Mb SubgroupsImmunogeneticsFunctional GenomicsImmune Cell SubpopulationsTumor Heterogeneity +13

clustifyr: an R package for automated single-cell RNA sequencing cluster classification

Rui Fu, Austin E. Gillen, Ryan M. Sheridan, +5

F1000Research

GeneticsTranscriptomics TechnologyGenomicsBioinformatics DatabaseGene Expression Profiling +23

Regulation of epithelial transitional states in murine and human pulmonary fibrosis

Fa Wang, Christopher Ting, Kent Riemondy, +17

Journal of Clinical Investigation

TCR signal strength controls thymic differentiation of iNKT cell subsets

Kathryn D. Tuttle, S. Harsha Krovi, Jingjing Zhang, +13

Nature Communications

Alternative RNA structures formed during transcription depend on elongation rate and modify RNA processing

Tassa Saldi, Kent Riemondy, Benjamin Erickson, +1

Molecular Cell

Transcriptional RegulationDevelopmental BiologyElongation RateNatural SciencesGenetics +10

Overexpression of Pendrin in Intercalated Cells Produces Chloride-Sensitive Hypertension

Thibaut Jacques, Nicolas Picard, R. Lance Miller, +14

Journal of the American Society of Nephrology