Svetlana Komarnitsky

Inhibiting Glycosphingolipid Synthesis Improves Glycemic Control and Insulin Sensitivity in Animal Models of Type 2 Diabetes

Hongmei Zhao, Malgorzata Przybylska, I-Huan Wu et al. · Diabetes · 2007 · 238 citations · Full text

Glycobiology, Insulin Receptor, Glucose Tolerance +19

A specific and potent inhibitor of glucosylceramide synthase for substrate inhibition therapy of Gaucher disease

Kerry Anne McEachern, John J. Fung, Svetlana Komarnitsky et al. · Molecular Genetics and Metabolism · 2007 · 175 citations

Gaucher Disease, Biochemistry, Medicine +8

Inhibition of glucosylceramide accumulation results in effective blockade of polycystic kidney disease in mouse models

Thomas A. Natoli, Laurie A. Smith, Kelly A. Rogers et al. · Nature Medicine · 2010 · 172 citations · Full text

Inflammation, Glomerulonephritis, Renal Function +12

SCD1 Inhibition Causes Cancer Cell Death by Depleting Mono-Unsaturated Fatty Acids

Paul Mason, Beirong Liang, Lingyun Li et al. · PLoS ONE · 2012 · 166 citations · Full text

Pathology, Cell Death, Reference Scd1 Inhibitors +16