Concepedia

A specific and potent inhibitor of glucosylceramide synthase for substrate inhibition therapy of Gaucher disease

Kerry Anne McEachern, John J. Fung, Svetlana Komarnitsky, Craig Siegel, Wei‐Lien Chuang, Elizabeth Hutto, James A. Shayman, Gregory A. Grabowski, Johannes M. F. G. Aerts, Seng H. Cheng,

Molecular Genetics and Metabolism · 2007 · 178 citations · 31 references

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References

31

Replacement Therapy for Inherited Enzyme Deficiency — Macrophage-Targeted Glucocerebrosidase for Gaucher's Disease

Norman W. Barton, Roscoe O. Brady, James M. Dambrosia et al. · New England Journal of Medicine · 1991 · 1.3K citations · Full text

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Novel oral treatment of Gaucher's disease with N-butyldeoxynojirimycin (OGT 918) to decrease substrate biosynthesis

Timothy M. Cox, Robin Lachmann, C. E. Hollak et al. · The Lancet · 2000 · 744 citations

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Effectiveness of enzyme replacement therapy in 1028 patients with type 1 Gaucher disease after 2 to 5 years of treatment: a report from the Gaucher Registry

Neal J. Weinreb, Joel Charrow, Hans C. Andersson et al. · The American Journal of Medicine · 2002 · 541 citations

, , +9

Pharmacological Inhibition of Glucosylceramide Synthase Enhances Insulin Sensitivity

Johannes M. F. G. Aerts, Roelof Ottenhoff, Andrew Powlson et al. · Diabetes · 2007 · 297 citations · Full text

, , +17

Improved Inhibitors of Glucosylceramide Synthase

Lihsueh Lee, Akira Abe, James A. Shayman · Journal of Biological Chemistry · 1999 · 242 citations · Full text

, , +15