S. Tiong Ong

A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer

King Pan Ng, Axel M. Hillmer, Charles Chuah et al. · Nature Medicine · 2012 · 550 citations

Intrinsic Resistance, Tumor Biology, Radiation Oncology +11

Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor

Matthew R. Janes, Jose J. Limon, Lomon So et al. · Nature Medicine · 2010 · 334 citations · Full text

Tumor Biology, Medicine, Malignant Blood Disorder +11

FHIT and FRA3B 3p14.2 allele loss are common in lung cancer and preneoplastic bronchial lesions and are associated with cancer-related FHIT cDNA splicing aberrations.

Kwun M. Fong, Eric J. Biesterveld, Arvind K. Virmani et al. · PubMed · 1997 · 195 citations

Primary Nsclc Cancers, Genetics, Pathology +17

Bcr-Abl kinase modulates the translation regulators ribosomal protein S6 and 4E-BP1 in chronic myelogenous leukemia cells via the mammalian target of rapamycin.

Chi Ly, Adrian F. Arechiga, Junia V. Melo et al. · PubMed · 2003 · 158 citations

Mixed-phenotype Acute Leukemia, Bcr-abl Kinase, Immunology +17

Targeting of the MNK–eIF4E axis in blast crisis chronic myeloid leukemia inhibits leukemia stem cell function

Sharon Lim, Tzuen Yih Saw, Min Zhang et al. · Proceedings of the National Academy of Sciences · 2013 · 140 citations · Full text