Kazuhiko Shigeno

Discovery of 3-Ethyl-4-(3-isopropyl-4-(4-(1-methyl-1<i>H</i>-pyrazol-4-yl)-1<i>H</i>-imidazol-1-yl)-1<i>H</i>-pyrazolo[3,4-<i>b</i>]pyridin-1-yl)benzamide (TAS-116) as a Potent, Selective, and Orally Available HSP90 Inhibitor

Takao Uno, Yuichi Kawai, Satoshi Yamashita et al. · Journal of Medicinal Chemistry · 2018 · 55 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

Steroidal oxathiazine inhibitors of estrone sulfatase

Richard H. Peters, Wan-Ru Chao, Barbara Sato et al. · Steroids · 2002 · 45 citations

Life Sciences, Biochemistry, Pharmacology +14

Synthetic studies towards phorbols: A stereocontrolled synthesis of the phorbol skeleton in the naturally occurring form

Kazuhiko Shigeno, Hiroaki Sasai, Masakatsu Shibasaki · Tetrahedron Letters · 1992 · 29 citations

Natural Sciences, Biochemistry, Medicinal Chemistry +6

The antibodies against 5-bromo-2′-deoxyuridine specifically recognize trifluridine incorporated into DNA

Hiroyuki Kitao, Yosuke Morodomi, Shinichiro Niimi et al. · Scientific Reports · 2016 · 27 citations · Full text

Medicine, Molecular Biology, Oncology +13

Synthetic Approaches to Phorbols via the Intramolevular Nitrile Oxide Cycloaddition: Stereocontrol of the B-C Ring Junction

Masakatsu Shibasaki, Kazuhiko Shigeno, Kazuhiko Ohne et al. · Heterocycles · 1992 · 19 citations · Full text

Natural Sciences, Chemistry, Medicinal Chemistry +11