Synthetic studies towards phorbols: A stereocontrolled synthesis of the phorbol skeleton in the naturally occurring form

Organocerium reagents. Nucleophilic addition to easily enolizable ketones

Tsuneo Imamoto, Yasushi Sugiura, Nobuyuki Takiyama · Tetrahedron Letters · 1984 · 268 citations

Natural Sciences, Chemistry, Medicinal Chemistry +10

Modeling of the bryostatins to the phorbol ester pharmacophore on protein kinase C.

Paul A. Wender, C. M. CRIBBS, Konrad F. Koehler et al. · Proceedings of the National Academy of Sciences · 1988 · 201 citations · Full text

Pharmacy, Biochemistry, Pharmacology +17

Studies on tumor promoters. 9. A second-generation synthesis of phorbol

Paul A. Wender, Frank E. McDonald · Journal of the American Chemical Society · 1990 · 176 citations

Medicine, Oncology, Pharmacology +7

Analysis of the phorbol ester pharmacophore on protein kinase C as a guide to the rational design of new classes of analogs.

Paul A. Wender, Konrad F. Koehler, Nancy A. Sharkey et al. · Proceedings of the National Academy of Sciences · 1986 · 155 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Studies on tumor promoters. 8. The synthesis of phorbol

Paul A. Wender, Hiroshi Kogen, Hee Yoon Lee et al. · Journal of the American Chemical Society · 1989 · 144 citations

Medicine, Oncology, Pharmacology +7