Identification of preexisting adaptive immunity to Cas9 proteins in humans

Carsten T. Charlesworth, Priyanka S. Deshpande, Daniel P. Dever, +17

Nature Medicine

Immunological MemoryImmunogeneticsCas9 ProteinsAutoimmune DiseaseAdaptive Immune System +8

CRISPR/Cas9 β-globin gene targeting in human haematopoietic stem cells

Daniel P. Dever, Rasmus O. Bak, Andreas Reinisch, +13

Nature

Crispr/cas9 β-Globin GeneStem Cell ResearchGene EditingGenome EditingMedicine +2

A high-fidelity Cas9 mutant delivered as a ribonucleoprotein complex enables efficient gene editing in human hematopoietic stem and progenitor cells

Christopher A. Vakulskas, Daniel P. Dever, Garrett R. Rettig, +17

Nature Medicine

Highly Efficient and Marker-free Genome Editing of Human Pluripotent Stem Cells by CRISPR-Cas9 RNP and AAV6 Donor-Mediated Homologous Recombination

Renata M. Martin, Kazuya Ikeda, M. Kyle Cromer, +18

Cell stem cell

Induced Pluripotent Stem CellEngineeringMedicineGenetic EngineeringStem Cell Research +11

Gene correction for SCID-X1 in long-term hematopoietic stem cells

Mara Pavel-Dinu, Volker Wiebking, Beruh Dejene, +15

Nature Communications

Identification of Pre-Existing Adaptive Immunity to Cas9 Proteins in Humans

Carsten T. Charlesworth, Priyanka S. Deshpande, Daniel P. Dever, +7

Adaptive Immune SystemInnate Immune SystemImmunologyInnate ImmunityImmune System +18

CRISPR-based gene editing enables <i>FOXP3</i> gene repair in IPEX patient cells

Marianne Goodwin, E. Lee, Uma Lakshmanan, +19

Science Advances

High-efficiency transgene integration by homology-directed repair in human primary cells using DNA-PKcs inhibition

Sridhar Selvaraj, William N. Feist, Sébastien Viel, +13

Nature Biotechnology

ChromatinGenome InstabilityNatural SciencesMolecular BiologyDna Replication +7

Discovery-Based Science Education: Functional Genomic Dissection in Drosophila by Undergraduate Researchers

Jiong Chen, Gerald B. Call, Elsa Beyer, +142

PLoS Biology

Enhanced homology-directed repair for highly efficient gene editing in hematopoietic stem/progenitor cells

Suk See De Ravin, Julie Brault, Ronald J. Meis, +20

Blood