Potentiating the antitumour response of CD8+ T cells by modulating cholesterol metabolism

Wei Yang, Yibing Bai, Ying Xiong, +19

Nature

InflammationCholesterol MetabolismMedicineT-regulatory CellImmunology +8

Regulation of T Cell Receptor Activation by Dynamic Membrane Binding of the CD3ɛ Cytoplasmic Tyrosine-Based Motif

Chenqi Xu, Étienne Gagnon, Matthew E. Call, +5

Cell

Signal TransductionT-regulatory CellImmunologyImmunologic MechanismAntigen Processing +7

Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein

Kevin C. O’Connor, Katherine A. McLaughlin, Philip L. De Jager, +23

Nature Medicine

Autoimmune DiseaseAllergyAutoantibody ProductionSelf-antigen TetramersMedicine +10

FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cells

Xiangbo Meng, Xiwei Liu, Xingdong Guo, +14

Nature

Pd-1 UbiquitinationCancer ImmunosurveillanceT CellsT-regulatory CellImmunology +10

Ca2+ regulates T-cell receptor activation by modulating the charge property of lipids

Xiaoshan Shi, Yunchen Bi, Wei Yang, +13

Nature

Proteinlipid InteractionSignal TransductionCell SignalingT-regulatory CellPhysiology +10

The Structure of the ζζ Transmembrane Dimer Reveals Features Essential for Its Assembly with the T Cell Receptor

Matthew E. Call, Jason R. Schnell, Chenqi Xu, +3

Cell

Signal TransductionNatural SciencesT-regulatory CellReceptor (Biochemistry)Molecular Biology +8

Multiple Signaling Roles of CD3ε and Its Application in CAR-T Cell Therapy

Wei Wu, Qiuping Zhou, Takeya Masubuchi, +15

Cell

Signal TransductionT-regulatory CellImmunologyCar-t Cell TherapyImmunologic Mechanism +10

Exhaustion-associated cholesterol deficiency dampens the cytotoxic arm of antitumor immunity

Chengsong Yan, Lin Zheng, Shutan Jiang, +16

Cancer Cell

InflammationExhaustion-associated Cholesterol DeficiencyOxysterolAutoimmune DiseaseApoptosis +9

Regulation of EGFR nanocluster formation by ionic protein-lipid interaction

Ye Wang, Jing Gao, Xingdong Guo, +10

Cell Research

BiophysicsNanoclusterEgfr Nanocluster Formation

Mechano-regulation of Peptide-MHC Class I Conformations Determines TCR Antigen Recognition

Peng Wu, Tongtong Zhang, Baoyu Liu, +21

Molecular Cell

HistocompatibilitySignal TransductionImmune Effector FunctionsPeptide-mhc ClassImmunology +5