Ca2+ regulates T-cell receptor activation by modulating the charge property of lipids

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T Cell Receptor-Proximal Signals Are Sustained in Peripheral Microclusters and Terminated in the Central Supramolecular Activation Cluster

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Life Sciences, Cell Biology, Immunology +16

Direct observation of ligand recognition by T cells

Darrell J. Irvine, Marco A. Purbhoo, Michelle Krogsgaard et al. · Nature · 2002 · 822 citations

Life Sciences, Immunology, Molecular Biology +16

Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai

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