Pierre Pirot

Induction of nuclear factor-κB and its downstream genes by TNF-α and IL-1β has a pro-apoptotic role in pancreatic beta cells

Fernanda Ortis, Pierre Pirot, Najib Naamane et al. · Diabetologia · 2008 · 155 citations · Full text

Inflammation, Cytokine, Immune Cell Development +10

Sustained production of spliced X-box binding protein 1 (XBP1) induces pancreatic beta cell dysfunction and apoptosis

Florent Allagnat, Fotini Christulia, Fernanda Ortis et al. · Diabetologia · 2010 · 132 citations · Full text

Protein Function, Molecular Physiology, Signal Transduction +7

Global profiling of genes modified by endoplasmic reticulum stress in pancreatic beta cells reveals the early degradation of insulin mRNAs

Pierre Pirot, Najib Naamane, Frédérick Libert et al. · Diabetologia · 2007 · 128 citations · Full text

Insulin Signaling, Protein Expression, Early Degradation +10

Transcriptional Regulation of the Endoplasmic Reticulum Stress Gene Chop in Pancreatic Insulin-Producing Cells

Pierre Pirot, Fernanda Ortis, Miriam Cnop et al. · Diabetes · 2007 · 109 citations · Full text

Molecular Regulation, Apoptosis, Immunology +19

Interferon-γ potentiates endoplasmic reticulum stress-induced death by reducing pancreatic beta cell defence mechanisms

Pierre Pirot, Décio L. Eizirik, Alessandra K. Cardozo · Diabetologia · 2006 · 87 citations · Full text

Inflammation, Cytokine, Signal Transduction +8