Partition coefficient and diffusion coefficient determinations of 50 compounds in human intact skin, isolated skin layers and isolated stratum corneum lipids

Corie A. Ellison, Kevin O. Tankersley, Cindy Obringer, +12

Toxicology in Vitro

Lipid AnalysisDermatologyPartition CoefficientDermatomed Human SkinHuman Intact Skin +18

Comparison of protocols measuring diffusion and partition coefficients in the stratum corneum

H. Rothe, Cindy Obringer, John Manwaring, +11

Journal of Applied Toxicology

Intrinsic relative potency of a series of pyrrolizidine alkaloids characterized by rate and extent of metabolism

Cathy Lester, John Troutman, Cindy Obringer, +8

Food and Chemical Toxicology

BiochemistryMedicineSecondary MetabolitePyrrolizidine AlkaloidsMetabolomics +5

Extrapolation of systemic bioavailability assessing skin absorption and epidermal and hepatic metabolism of aromatic amine hair dyes in vitro

John Manwaring, Helga Rothe, Cindy Obringer, +5

Toxicology and Applied Pharmacology

Human Skin ExplantsSkin Permeability CoefficientDermatologyBioanalysisToxicology +19

Effect of chain length and branching on the in vitro metabolism of a series of parabens in human liver S9, human skin S9, and human plasma

Cindy Obringer, Shengde Wu, John Troutman, +2

Regulatory Toxicology and Pharmacology

Health SciencesBiochemistryChain LengthMedicineLiver Physiology +12

Discovery of Orally Bioavailable 1,3,4-Trisubstituted 2-Oxopiperazine-Based Melanocortin-4 Receptor Agonists as Potential Antiobesity Agents

Xinrong Tian, Adrian G. Switzer, Steve A. Derose, +19

Journal of Medicinal Chemistry

Medicinal ChemistryPharmacological StudyBiochemistryFunctional SelectivityBasic Guanidine Moiety +11

Suitability of the in vitro Caco-2 assay to predict the oral absorption of aromatic amine hair dyes

Cindy Obringer, John Manwaring, Carsten Goebel, +2

Toxicology in Vitro

Pharmaceutical ScienceHair DyesPharmacokinetic ModelingBiochemistryGastrointestinal Pharmacology +12

Design, Synthesis, and Evaluation of Proline and Pyrrolidine Based Melanocortin Receptor Agonists. A Conformationally Restricted Dipeptide Mimic Approach

Xinrong Tian, Timothy B. Field, Adrian G. Switzer, +10

Journal of Medicinal Chemistry

Medicinal ChemistryPharmaceutical ChemistryBiochemistryFunctional SelectivityNatural Sciences +12

Novel pyrazolopiperazinone- and pyrrolopiperazinone-based MCH-R1 antagonists

Kenneth M. Meyers, José Méndez-Andino, Anny‐Odile Colson, +9

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinal ChemistryMedicineRational Drug DesignPharmacological Agent +5

Structure-activity relationship read-across and transcriptomics for branched carboxylic acids

Shengde Wu, Corie A. Ellison, Jorge M. Naciff, +7

Toxicological Sciences