Investigation of Peptide Reactivity of Pro-hapten Skin Sensitizers Using a Peroxidase-Peroxide Oxidation System

G. Frank Gerberick, John Troutman, Leslie M. Foertsch, +5

Toxicological Sciences

Skin ProteinSkin AllergyDermatologyRedox BiologyOxidative Stress +15

The Incorporation of Lysine into the Peroxidase Peptide Reactivity Assay for Skin Sensitization Assessments

John Troutman, Leslie M. Foertsch, Petra Kern, +6

Toxicological Sciences

Introduction of a methoxymethyl side chain into p-phenylenediamine attenuates its sensitizing potency and reduces the risk of allergy induction

Carsten Goebel, John Troutman, Jenny Hennen, +4

Toxicology and Applied Pharmacology

Sensitizing PotencyMedicinal ChemistryAllergyAllergy MedicineMedicine +9

Development of a physiologically-based pharmacokinetic model of 2-phenoxyethanol and its metabolite phenoxyacetic acid in rats and humans to address toxicokinetic uncertainty in risk assessment

John Troutman, David L. Rick, Sharon B. Stuard, +2

Regulatory Toxicology and Pharmacology

Pharmacokinetic ModelingPharmacological StudyMedicinePhysiologyToxicology +9

Cosmetics Europe evaluation of 6 in silico skin penetration models

Sebastien Grégoire, Ian Sorrell, Daniela Lange, +10

Computational Toxicology

Dd PredictionAdme TfPharmacokinetic ModelingCosmetic SurgeryMedicine +12

Reactivity of chemical respiratory allergens in the Peroxidase Peptide Reactivity Assay

J. Lalko, Rebecca J. Dearman, G. Frank Gerberick, +3

Toxicology in Vitro

AsthmaEnvironmental AllergyAllergyBiochemistryChemical Respiratory Allergens +9

Intrinsic relative potency of a series of pyrrolizidine alkaloids characterized by rate and extent of metabolism

Cathy Lester, John Troutman, Cindy Obringer, +8

Food and Chemical Toxicology

BiochemistryMedicineSecondary MetabolitePyrrolizidine AlkaloidsMetabolomics +5

Extrapolation of systemic bioavailability assessing skin absorption and epidermal and hepatic metabolism of aromatic amine hair dyes in vitro

John Manwaring, Helga Rothe, Cindy Obringer, +5

Toxicology and Applied Pharmacology

Human Skin ExplantsSkin Permeability CoefficientDermatologyBioanalysisToxicology +19

Effect of chain length and branching on the in vitro metabolism of a series of parabens in human liver S9, human skin S9, and human plasma

Cindy Obringer, Shengde Wu, John Troutman, +2

Regulatory Toxicology and Pharmacology

Health SciencesBiochemistryChain LengthMedicineLiver Physiology +12

Development of growth equations from longitudinal studies of body weight and height in the full term and preterm neonate: From birth to four years postnatal age

John Troutman, Mary C. Sullivan, Gregory J. Carr, +1

Birth Defects Research