The Peroxisome Proliferator-activated Receptor γ Regulates Expression of the Perilipin Gene in Adipocytes

Naoto Arimura, Taro Horiba, Masayoshi Imagawa, +2

Journal of Biological Chemistry

Cholesterol-functionalized DNA/RNA heteroduplexes cross the blood–brain barrier and knock down genes in the rodent CNS

Tetsuya Nagata, Chrissa A. Dwyer, Kie Yoshida‐Tanaka, +20

Nature Biotechnology

Knockout MouseChromatinNeurodegenerative DiseasesMolecular NeuroscienceNeurogenomics +13

Sterol Regulatory Element-binding Protein-2 Interacts with Hepatocyte Nuclear Factor-4 to Enhance Sterol Isomerase Gene Expression in Hepatocytes

Koichi Misawa, Taro Horiba, Naoto Arimura, +6

Journal of Biological Chemistry

Perilipin-Mediated Lipid Droplet Formation in Adipocytes Promotes Sterol Regulatory Element-Binding Protein-1 Processing and Triacylglyceride Accumulation

Yu Takahashi, Akihiro Shinoda, Norihiko Furuya, +6

PLoS ONE

Design, Synthesis, and Evaluation of Piperazinyl Pyrrolidin-2-ones as a Novel Series of Reversible Monoacylglycerol Lipase Inhibitors

Jumpei Aida, Makoto Fushimi, Tomokazu Kusumoto, +7

Journal of Medicinal Chemistry

Magl EnzymeMedicinal ChemistryPiperazinyl Pyrrolidin-2-one CorePiperazinyl Pyrrolidin-2-onesNovel Series +13

A new class of non-thiazolidinedione, non-carboxylic-acid-based highly selective peroxisome proliferator-activated receptor (PPAR) γ agonists: Design and synthesis of benzylpyrazole acylsulfonamides

Kentaro Rikimaru, Takeshi Wakabayashi, Hidenori Abe, +21

Bioorganic & Medicinal Chemistry

Pharmaceutical ScienceDiversity Oriented SynthesisBiochemistryMedicineBenzylpyrazole Acylsulfonamides +7

Design, Synthesis, and Evaluation of (4<i>R</i>)-1-{3-[2-(¹⁸F)Fluoro-4-methylpyridin-3-yl]phenyl}-4-[4-(1,3-thiazol-2-ylcarbonyl)piperazin-1-yl]pyrrolidin-2-one ([¹⁸F]<b>T-401</b>) as a Novel Positron-Emission Tomography Imaging Agent for Monoacylglycerol Lipase

Yasushi Hattori, Kazunobu Aoyama, Jun Maeda, +11

Journal of Medicinal Chemistry

Anti-sortilin1 Antibody Up-Regulates Progranulin via Sortilin1 Down-Regulation

Shuuichi Miyakawa, Hiroyuki Sakuma, Dnyaneshwar Warude, +13

Frontiers in Neuroscience

Design and Synthesis of Novel Spiro Derivatives as Potent and Reversible Monoacylglycerol Lipase (MAGL) Inhibitors: Bioisosteric Transformation from 3-Oxo-3,4-dihydro-2<i>H</i>-benzo[<i>b</i>][1,4]oxazin-6-yl Moiety

Shuhei Ikeda, Hideyuki Sugiyama, Hidekazu Tokuhara, +16

Journal of Medicinal Chemistry

Structure–activity relationships and key structural feature of pyridyloxybenzene-acylsulfonamides as new, potent, and selective peroxisome proliferator-activated receptor (PPAR) γ Agonists

Kentaro Rikimaru, Takeshi Wakabayashi, Hidenori Abe, +22

Bioorganic & Medicinal Chemistry

BiochemistryMedicineNatural Sciencesγ AgonistsMechanism Of Action +6