Motoki Sawamura

Evaluation of the effects of chemically different linkers on hepatic accumulations, cell tropism and gene silencing ability of cholesterol-conjugated antisense oligonucleotides

Shunsuke Wada, Hidenori Yasuhara, Fumito Wada et al. · Journal of Controlled Release · 2016 · 48 citations

Cholesterol-conjugated Antisense Oligonucleotides, Oxysterol, Biochemistry +8

Serial incorporation of a monovalent GalNAc phosphoramidite unit into hepatocyte-targeting antisense oligonucleotides

Tsuyoshi Yamamoto, Motoki Sawamura, Fumito Wada et al. · Bioorganic & Medicinal Chemistry · 2015 · 47 citations

Hepatocyte-targeting Antisense Oligonucleotides, Bioorganic Chemistry, Biochemistry +7

Cholesterol–GalNAc Dual Conjugation Strategy for Reducing Renal Distribution of Antisense Oligonucleotides

Fumito Wada, Tsuyoshi Yamamoto, Tetsuya Ueda et al. · Nucleic Acid Therapeutics · 2018 · 21 citations

Renal Function, Ligand Conjugation Strategy, Biochemistry +13

Triazole- and Tetrazole-Bridged Nucleic Acids: Synthesis, Duplex Stability, Nuclease Resistance, and in Vitro and in Vivo Antisense Potency

Yasunori Mitsuoka, Tsuyoshi Yamamoto, Akira Kugimiya et al. · The Journal of Organic Chemistry · 2016 · 17 citations

Nucleic Acid Chemistry, Nuclease Resistance, Biochemistry +11

Synthesis, duplex-forming ability, enzymatic stability, and in vitro antisense potency of oligonucleotides including 2′-C,4′-C-ethyleneoxy-bridged thymidine derivatives

Takashi Osawa, Motoki Sawamura, Fumito Wada et al. · Organic & Biomolecular Chemistry · 2017 · 14 citations