Hidenori Yasuhara

DNA/RNA heteroduplex oligonucleotide for highly efficient gene silencing

Kazutaka Nishina, Wenying Piao, Kie Yoshida‐Tanaka et al. · Nature Communications · 2015 · 126 citations · Full text

Life Sciences, Biotechnology, Molecular Biology +14

Evaluation of off‐target effects of gapmer antisense oligonucleotides using human cells

Tokuyuki Yoshida, Yuki Naito, Hidenori Yasuhara et al. · Genes to Cells · 2019 · 77 citations · Full text

Life Sciences, Molecular Biology, Molecular Genetics +13

Cholesterol-lowering Action of BNA-based Antisense Oligonucleotides Targeting PCSK9 in Atherogenic Diet-induced Hypercholesterolemic Mice

Tsuyoshi Yamamoto, Mariko Harada‐Shiba, Moeka Nakatani et al. · Molecular Therapy — Nucleic Acids · 2012 · 69 citations · Full text

Life Sciences, Molecular Biology, Pharmacology +16

Amido-bridged nucleic acids with small hydrophobic residues enhance hepatic tropism of antisense oligonucleotides in vivo

Tsuyoshi Yamamoto, Aiko Yahara, Reiko Waki et al. · Organic & Biomolecular Chemistry · 2015 · 51 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

Evaluation of the effects of chemically different linkers on hepatic accumulations, cell tropism and gene silencing ability of cholesterol-conjugated antisense oligonucleotides

Shunsuke Wada, Hidenori Yasuhara, Fumito Wada et al. · Journal of Controlled Release · 2016 · 48 citations

Pharmacy, Biochemistry, Molecular Biology +16