Kwok‐Kin Wong

A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations

Sreenath V. Sharma, Diana Lee, Bihua Li et al. · Cell · 2010 · 2.7K citations · Full text

Chromatin, Chromatin Remodeling, Medicine +6

The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP

Cai‐Hong Yun, Kristen E. Mengwasser, Angela V. Toms et al. · Proceedings of the National Academy of Sciences · 2008 · 2.1K citations · Full text

Atp Binding Pocket, Molecular Biology, T790m Mutation +20

<i>STK11/LKB1</i> Mutations and PD-1 Inhibitor Resistance in <i>KRAS</i>-Mutant Lung Adenocarcinoma

Ferdinandos Skoulidis, Michael E. Goldberg, Danielle Greenawalt et al. · Cancer Discovery · 2018 · 1.5K citations · Full text

Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints

Shohei Koyama, Esra A. Akbay, Yvonne Y. Li et al. · Nature Communications · 2016 · 1.5K citations · Full text

The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins

Gang Lu, Richard E. Middleton, Huahang Sun et al. · Science · 2013 · 1.5K citations · Full text

Hematological Malignancy, Cereblon-dependent Destruction, Developmental Biology +15