Bcl-2 family proteins are essential for platelet survival

H Zhang, Paul Nimmer, Stephen K Tahir, +13

Cell Death and Differentiation

ThrombopoiesisThrombosisBlood PlateletImmunologyHematology +6

Comparative effects of levosimendan, OR-1896, OR-1855, dobutamine, and milrinone on vascular resistance, indexes of cardiac function, and O₂consumption in dogs

Patricia N. Banfor, Lee C. Preusser, Thomas Campbell, +5

American Journal of Physiology-Heart and Circulatory Physiology

Animal PhysiologyCardiac FunctionVeterinary PhysiologyMolecular PhysiologyMedicine +13

Discovery of ((4<i>R</i>,5<i>S</i>)-5-Amino-4-(2,4,5- trifluorophenyl)cyclohex-1-enyl)-(3- (trifluoromethyl)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazin-7(8<i>H</i>)-yl)methanone (ABT-341), a Highly Potent, Selective, Orally Efficacious, and Safe Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes

Zhonghua Pei, Xiaofeng Li, Thomas W von Geldern, +19

Journal of Medicinal Chemistry

Orally EfficaciousPharmacotherapyPharmaceutical ChemistryTranslational PharmacologyMolecular Pharmacology +16

Optimization of Chromone-2-carboxamide Melanin Concentrating Hormone Receptor 1 Antagonists:  Assessment of Potency, Efficacy, and Cardiovascular Safety

J.A. Lynch, Jennifer C. Freeman, Andrew S. Judd, +29

Journal of Medicinal Chemistry

Metabolic SyndromeMedicinal ChemistryDistinct SeriesPharmacological StudyMedicine +12

Discovery and Characterization of Aminopiperidinecoumarin Melanin Concentrating Hormone Receptor 1 Antagonists

Philip R. Kym, Rajesh Iyengar, Andrew J. Souers, +36

Journal of Medicinal Chemistry

Cardiovascular PharmacologyPharmacotherapyMetabolic SyndromePharmacological StudyMchr1 Antagonists +15

Hypertension induced by blockade of ET_Breceptors in conscious nonhuman primates: role of ET_Areceptors

Glenn A. Reinhart, Lee C. Preusser, Sandra E. Burke, +4

American Journal of Physiology-Heart and Circulatory Physiology

Thienopyridine ureas as dual inhibitors of the VEGF and Aurora kinase families

Michael L. Curtin, Robin R. Frey, H. Robin Heyman, +17

Bioorganic & Medicinal Chemistry Letters

Dual InhibitorsMedicineReceptor Tyrosine KinaseFibroblast Growth FactorAurora Kinase Families +4

Screening for Cardiovascular Safety:  A Structure−Activity Approach for Guiding Lead Selection of Melanin Concentrating Hormone Receptor 1 Antagonists

Philip R. Kym, Andrew J. Souers, Thomas Campbell, +23

Journal of Medicinal Chemistry

Cardiovascular Effects of Torcetrapib in Conscious and Pentobarbital-anesthetized Dogs

James S. Polakowski, Andrew King, Thomas Campbell, +7

Journal of Cardiovascular Pharmacology

(–)-(9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide (A-278637), a Novel ATP-Sensitive Potassium Channel Opener: Hemodynamic Comparison to ZD-6169, WAY-133537, and Nifedipine in the Anesthetized Canine

Ryan M. Fryer, Lee C. Preusser, Samuel V. Calzadilla, +7

Journal of Cardiovascular Pharmacology

Anesthetic MechanismPharmacotherapyExperimental PharmacologyNeuromuscular BlockadeMolecular Pharmacology +19